中华内科杂志
中華內科雜誌
중화내과잡지
CHINESE JOURNAL OF INTERNAL MEDICINE
2013年
5期
370-374
,共5页
唐睿晗%晁康%张盛洪%陈白莉%何瑶%高翔%曾志荣%胡品津%陈旻湖
唐睿晗%晁康%張盛洪%陳白莉%何瑤%高翔%曾誌榮%鬍品津%陳旻湖
당예함%조강%장성홍%진백리%하요%고상%증지영%호품진%진민호
Crohn病%贫血%危险因素
Crohn病%貧血%危險因素
Crohn병%빈혈%위험인소
Crohn disease%Anemia%Risk factors
目的 调查中国人群克罗恩病(CD)患者初次诊断时的贫血发生率及特征,探讨引起贫血的可能原因及危险因素.方法 纳入2003年1月至2012年5月于中山大学附属第一医院住院及门诊就诊的CD患者441例.分析确诊为CD患者首次就诊时贫血的发生率、严重程度及类型,并对其中资料齐全的122例患者进行多因素logistic回归分析,以探讨CD患者贫血发生的可能危险因素.结果 64.4％ (284/441)患者达到贫血标准,其中,轻度贫血占69.0％ (196/284),中度贫血占28.9％ (82/284),重度贫血占2.1％(6/284)；贫血类型以小细胞低色素性贫血为主(43.7％,124/284).多因素logistic回归分析提示,校正的克罗恩病疾病活动指数(CDAI)偏高(OR=1.007,95％ CI1.002～1.013)、血小板计数增加(OR=1.007,95％ CI1.001 ～1.012)、红细胞沉降率增加(OR=1.024,95％ CI1.000 ～1.048)、穿透型(OR=16.925,95％ CI2.626～ 108.626)或狭窄型(OR=6.717,95％ CI1.583 ～28.507)、确诊年龄大(OR=1.065,95％ CI1.012 ～1.121)及体重指数(BMI)偏低(OR=0.769,95％ CI0.633 ～0.935)均可能增加CD患者发生贫血的风险.结论 贫血是CD常见并发症.炎症活动、穿透型或狭窄型疾病行为、确诊年龄大、BMI低均为CD患者贫血的危险因素.
目的 調查中國人群剋囉恩病(CD)患者初次診斷時的貧血髮生率及特徵,探討引起貧血的可能原因及危險因素.方法 納入2003年1月至2012年5月于中山大學附屬第一醫院住院及門診就診的CD患者441例.分析確診為CD患者首次就診時貧血的髮生率、嚴重程度及類型,併對其中資料齊全的122例患者進行多因素logistic迴歸分析,以探討CD患者貧血髮生的可能危險因素.結果 64.4％ (284/441)患者達到貧血標準,其中,輕度貧血佔69.0％ (196/284),中度貧血佔28.9％ (82/284),重度貧血佔2.1％(6/284)；貧血類型以小細胞低色素性貧血為主(43.7％,124/284).多因素logistic迴歸分析提示,校正的剋囉恩病疾病活動指數(CDAI)偏高(OR=1.007,95％ CI1.002～1.013)、血小闆計數增加(OR=1.007,95％ CI1.001 ～1.012)、紅細胞沉降率增加(OR=1.024,95％ CI1.000 ～1.048)、穿透型(OR=16.925,95％ CI2.626～ 108.626)或狹窄型(OR=6.717,95％ CI1.583 ～28.507)、確診年齡大(OR=1.065,95％ CI1.012 ～1.121)及體重指數(BMI)偏低(OR=0.769,95％ CI0.633 ～0.935)均可能增加CD患者髮生貧血的風險.結論 貧血是CD常見併髮癥.炎癥活動、穿透型或狹窄型疾病行為、確診年齡大、BMI低均為CD患者貧血的危險因素.
목적 조사중국인군극라은병(CD)환자초차진단시적빈혈발생솔급특정,탐토인기빈혈적가능원인급위험인소.방법 납입2003년1월지2012년5월우중산대학부속제일의원주원급문진취진적CD환자441례.분석학진위CD환자수차취진시빈혈적발생솔、엄중정도급류형,병대기중자료제전적122례환자진행다인소logistic회귀분석,이탐토CD환자빈혈발생적가능위험인소.결과 64.4％ (284/441)환자체도빈혈표준,기중,경도빈혈점69.0％ (196/284),중도빈혈점28.9％ (82/284),중도빈혈점2.1％(6/284)；빈혈류형이소세포저색소성빈혈위주(43.7％,124/284).다인소logistic회귀분석제시,교정적극라은병질병활동지수(CDAI)편고(OR=1.007,95％ CI1.002～1.013)、혈소판계수증가(OR=1.007,95％ CI1.001 ～1.012)、홍세포침강솔증가(OR=1.024,95％ CI1.000 ～1.048)、천투형(OR=16.925,95％ CI2.626～ 108.626)혹협착형(OR=6.717,95％ CI1.583 ～28.507)、학진년령대(OR=1.065,95％ CI1.012 ～1.121)급체중지수(BMI)편저(OR=0.769,95％ CI0.633 ～0.935)균가능증가CD환자발생빈혈적풍험.결론 빈혈시CD상견병발증.염증활동、천투형혹협착형질병행위、학진년령대、BMI저균위CD환자빈혈적위험인소.
Objective To investigate the prevalence and characteristics of anemia among patients with Crohn's disease (CD) in Chinese population and identify the possible risk factors.Methods A crosssectional study was performed in 441 patients with CD enrolled from the First Affiliated Hospital of Sun YatSen University between January 2003 and May 2012.The prevalence,severity,type of anemia in these patients was assessed when diagnosis was confirmed.A multivariate logistic regression including 122 patients was performed to screen risk factors of anemia.Results The prevalence of anemia was 64.4％ (284/441)with 69.0％ (196/284) mild anemia,28.9％ (82/284) moderate anemia and 2.1％ (6/284) severe anemia.The most common morphological classification was hypochromic microcytic anemia (43.7％,124/284).Multivariate logistic regression showed the predictive factors for anemia were higher levels of modified Crohn's disease activity index (CDAI) (OR =1.007,95％ CI 1.002-1.013),platelet count(OR =1.007,95％ CI 1.001-1.012),erythrocyte sedimentation rate (OR =1.024,95％ CI 1.000-1.048),penetrating behavior (OR =16.952,95％ CI 2.626-108.626),structuring behavior(OR =6.717,95％ CI1.583-28.507),older age at diagnosis (OR =1.065,95％ CI 1.012-1.121),and lower body mass index (BMI) (OR =0.769,95％ CI O.633-0.935).Conclusions Anemia is a common complication in patients with CD among Chinese population.Activity of the underlying disease,older age at diagnosis,penetrating or structuring disease behavior and low BMI are the risk factors.
