CAJ | 학술논문

目的：研究肝脏富血供肿物中常见恶性病变肝细胞性肝癌（hepatocellular carcinoma，HCC）和肝脏良性病变局灶性结节性增生（focal nodular hyperplasia，FNH）、肝腺瘤（hepatic adenoma，HA）CD34显色、微血管密度（microvessel density，MVD）的差异及临床意义。方法分别对32例HCC、12例FNH及5例HA组织行CD34免疫组化染色，并对各组CD34显色结果及MVD进行比较分析。结果 CD34在HCC、FNH及HA组织中均有不同程度的阳性表达。HCC的MVD为（57.88±24.89）/mm2，低于良性组（FNH、HA）的MVD（112.59±14.56）/mm2，两者MVD比较差异有统计学意义（P<0.05）。结论 CD34作为血管内皮标志物不具有反映恶性肿瘤的特异性。MVD亦不能作为反映肝脏肿物诱导血管新生能力的特异性指标。HCC的MVD低于FNH、HA的MVD，可为影像学鉴别诊断提供病理学基础。
목적：연구간장부혈공종물중상견악성병변간세포성간암（hepatocellular carcinoma，HCC）화간장량성병변국조성결절성증생（focal nodular hyperplasia，FNH）、간선류（hepatic adenoma，HA）CD34현색、미혈관밀도（microvessel density，MVD）적차이급림상의의。방법분별대32례HCC、12례FNH급5례HA조직행CD34면역조화염색，병대각조CD34현색결과급MVD진행비교분석。결과 CD34재HCC、FNH급HA조직중균유불동정도적양성표체。HCC적MVD위（57.88±24.89）/mm2，저우량성조（FNH、HA）적MVD（112.59±14.56）/mm2，량자MVD비교차이유통계학의의（P<0.05）。결론 CD34작위혈관내피표지물불구유반영악성종류적특이성。MVD역불능작위반영간장종물유도혈관신생능력적특이성지표。HCC적MVD저우FNH、HA적MVD，가위영상학감별진단제공병이학기출。
Objective To investigate patterns of CD34 expression and microvessel density (MVD) in hepatocellular carcinoma (HCC),focal nodular hyperplasia(FNH)and hepatic adenoma(HA). Methods Samples from patients with HCC(n=32),FNH (n=12)and HA (n=5)were analyzed by immunohistochemistry using an anti-CD34 antibody.MVD was also measured in all samples. Results CD34 was expressed in all three types of hypervascular hepatic mass.The MVD was significantly lower in HCC than in the benign lessions FNH and HA (P<0.05). Conclusions The significantly lower MVD in HCC compared to FNH and HA may allow imaging-based diagnosis of the disease.