CAJ | 학술논문

目的探讨年龄40岁以上多发性大动脉炎(TA)患者发病的临床特征.方法将北京安贞医院收治的53例TA患者按年龄分为青年组(≤40岁,44例)和中年组(＞40岁,9例),对其临床特征进行回顾性分析.结果 53例rA患者中中年(40岁以上)发病患者占17％,该组患者易出现胸痛、胸闷及发热(均P＜0.05).实验室检查2组差异均无统计学意义(均P＞0.05).中年组不易出现肾动脉、腹主动脉受累及多处血管受累情况(均P＜0.05).临床分型中年组较少出现累及降主动脉、腹主动脉及肾动脉的分型(P=0.05).2组比较高血压、主动脉瓣反流及动脉瘤的发生差异均无统计学意义(均P＞0.05).胸主动脉受累是合并高血压的独立危险因素(P＜0.05)；升主动脉受累是合并主动脉瓣反流及动脉瘤形成的独立危险因素(P＜0.01；P＜0.05).结论重视中年发病TA患者的临床特征有助于早期诊断.
목적 탐토년령40세이상다발성대동맥염(TA)환자발병적림상특정.방법 장북경안정의원수치적53례TA환자안년령분위청년조(≤40세,44례)화중년조(＞40세,9례),대기림상특정진행회고성분석.결과 53례rA환자중중년(40세이상)발병환자점17％,해조환자역출현흉통、흉민급발열(균P＜0.05).실험실검사2조차이균무통계학의의(균P＞0.05).중년조불역출현신동맥、복주동맥수루급다처혈관수루정황(균P＜0.05).림상분형중년조교소출현루급강주동맥、복주동맥급신동맥적분형(P=0.05).2조비교고혈압、주동맥판반류급동맥류적발생차이균무통계학의의(균P＞0.05).흉주동맥수루시합병고혈압적독립위험인소(P＜0.05)；승주동맥수루시합병주동맥판반류급동맥류형성적독립위험인소(P＜0.01；P＜0.05).결론 중시중년발병TA환자적림상특정유조우조기진단.
Objective To explore the clinical features of takayasu's arteritis (TA) in over 40 years old patients.Methods We retrospectively analyzed manifestations and tests in 53 TA patients.Results Onset age in 17％ patients was over 40.Fever and chest pain were found in first-visit over 40 years old patients (P ＜ 0.05).Laboratory tests showed no differences between young and middle age patients.Patients over 40 had less renal artery,abdominal aortic and multiple vascular involvement (P ＜ 0.05).Thoracic aorta involvement was an independent risk factor of elevated blood pressure (P ＜ 0.05) ; ascending aorta involvement was an independent risk factor of aortic regurgitation (P ＜ 0.01) and combined aneurysm formation (P ＜ 0.05).Conclusion Early diagnosis and treatment are important for TA in over 40 years old patients.