CAJ | 학술논문

研究两类药物释放曲线对血管壁中药物浓度分布的影响，为药物洗脱支架（DES）的优化设计提供依据；建立三维支架-血管模型，采用数值方法分析了雷帕霉素和紫杉醇两种药物释放曲线下血管壁中药物的浓度分布；初始药物释放率的增大会导致初始血管壁内药物浓度的增大，但随着时间的增加，血管壁中的药物浓度均趋于平稳。两种药物释放曲线下血管壁中的药物浓度均是随着时间的变化先增加后减少的，相比来说，雷帕霉素血管壁中的药物浓度随着时间变化的趋势要比紫杉醇血管壁中的药物浓度随着时间变化的趋势平稳，并且雷帕霉素血管壁中的药物浓度分布要比紫杉醇中血管壁中的药物浓度分布均匀。血管壁中药物浓度变化趋势的平稳性以及药物浓度分布的均匀性表明，雷帕霉素药物释放曲线要优于紫杉醇药物释放曲线。
연구량류약물석방곡선대혈관벽중약물농도분포적영향，위약물세탈지가（DES）적우화설계제공의거；건립삼유지가-혈관모형，채용수치방법분석료뢰파매소화자삼순량충약물석방곡선하혈관벽중약물적농도분포；초시약물석방솔적증대회도치초시혈관벽내약물농도적증대，단수착시간적증가，혈관벽중적약물농도균추우평은。량충약물석방곡선하혈관벽중적약물농도균시수착시간적변화선증가후감소적，상비래설，뢰파매소혈관벽중적약물농도수착시간변화적추세요비자삼순혈관벽중적약물농도수착시간변화적추세평은，병차뢰파매소혈관벽중적약물농도분포요비자삼순중혈관벽중적약물농도분포균균。혈관벽중약물농도변화추세적평은성이급약물농도분포적균균성표명，뢰파매소약물석방곡선요우우자삼순약물석방곡선。
To study the effects of two drug release profiles on the drug concentration for better design of drug -eluting stents (DES).A 3D virtual drug -eluting -vessel stent was modeled,and numerical simulation was used to investigate the drug concentration within the vessel wall at the drug release profile of rapamycin and paclitaxel,The initial drug concentration was increased with initial drug release rate increasing,but over time the drug concentration in the vessel wall would be stabilized.The drug concentrations pro-duced by both drug release profiles were first increased and then decreased with time,and compared with the concentration variation trend of paclitaxel,the concentration variation trend of rapamycin was steadier.In addition,the rapamycin concentration distribution in the vessel wall was more uniform than the paclitaxel concentration distribution.The stability of the drug concentration variation trend and the uniformity of drug concentration within the vessel wall show that rapamycin release profile is better than paclitaxel release profile.