CAJ | 학술논문

目的：探讨周剂量多西他赛同步三维适形放疗治疗老年非小细胞肺癌的临床疗效。方法选择2009年6月至2011年12月我院收治的85例老年非小细胞肺癌患者为研究对象，将其随机分为同步放化疗组（46例）和单纯放疗组（39例）。两组均行三维适形放疗累及野照射，2～2.6 Gy/次，5次/w，总照射剂量60～70 Gy，中位剂量66 Gy。同步放化疗组同时给予多西他赛化疗，30 mg·m-2，1次/周，共5～6周。治疗结束后，评价和比较两组的临床疗效及不良反应的发生情况。结果同步放化疗组和单纯放疗组的治疗总有效率分别为84.8％和64.1％，同步放化疗组显著高于单纯放疗组（P<0.05）；两组1年总生存率分别为82.7％、65.1％，差异无统计学意义（P>0.05）；1年无进展生存率分别为64.9％、40.6％，差异有统计学意义（P<0.05）。同步放化疗组造血系统毒性较单纯放疗组增加，但经处理后均能顺利完成治疗。结论与单纯放疗比较，周剂量多西他赛联合三维适形放疗能提高老年非小细胞肺癌的近期疗效，且毒副反应患者均能耐受。
목적：탐토주제량다서타새동보삼유괄형방료치료노년비소세포폐암적림상료효。방법선택2009년6월지2011년12월아원수치적85례노년비소세포폐암환자위연구대상，장기수궤분위동보방화료조（46례）화단순방료조（39례）。량조균행삼유괄형방료루급야조사，2～2.6 Gy/차，5차/w，총조사제량60～70 Gy，중위제량66 Gy。동보방화료조동시급여다서타새화료，30 mg·m-2，1차/주，공5～6주。치료결속후，평개화비교량조적림상료효급불량반응적발생정황。결과동보방화료조화단순방료조적치료총유효솔분별위84.8％화64.1％，동보방화료조현저고우단순방료조（P<0.05）；량조1년총생존솔분별위82.7％、65.1％，차이무통계학의의（P>0.05）；1년무진전생존솔분별위64.9％、40.6％，차이유통계학의의（P<0.05）。동보방화료조조혈계통독성교단순방료조증가，단경처리후균능순리완성치료。결론여단순방료비교，주제량다서타새연합삼유괄형방료능제고노년비소세포폐암적근기료효，차독부반응환자균능내수。
Objective To investigate the clinical effects of weekly docetaxel with synchronous conformal radiotherapy on eld-erly patients with non-small cell lung cancer. Methods A total of 85 elderly patients with non-small cell lung cancer admitted in our hospital between June 2009 and December 2011 were selected and randomly divided into chemoradiotherapy group (C+R group, n=46) and radiotherapy group (R group, n=39). All patients were treated with three-dimensional conformal radiation (2~2.6 Gy per fraction, total dose of 60~70 Gy), and the patients in the chemoradiotherapy group were also given weekly 30 mg·m-2 of docetaxel intravenously for 5~6 weeks. The efficacy and adverse reactions were compared between the two groups. Results The overall response rates (CR+PR) were 84.8%and 64.1%in the chemoradiotherapy group and radiotherapy group respectively (P<0.05). The one-year overall survival rates were 82.7%and 65.1%respectively in the two groups (P>0.05), and one-year progression-free survival rates were 64.9%and 40.6%respectively (P<0.05). The incidence of hematological toxic-ity was higher in the chemoradiotherapy group than in the radiotherapy group, but all therapy plans were successfully completed. Conclusions Compared with radiotherapy alone, weekly docetaxel combined with three-dimensional conformal radiotherapy could improve the short-term efficacy on elderly patients with non-small cell lung cancer, and the side effects were tolerated.