CAJ | 학술논문

目的：探讨SIRT1基因多态性与肺癌对以铂类为基础的化疗敏感性的关系。方法选取338名肺癌患者（其中184名对化疗耐药和154名对化疗敏感）为研究对象，所有患者均接受以铂类（顺铂、卡铂）为基础的化疗。分析其SIRT1的所有单核苷酸多态性，最后筛选出4个tag SNPs进行基因分型。OR和CI用来评估SIRT1基因多态性与肺癌患者化疗效果的相关性。结果在>60岁的肺癌患者中，rs3758391的基因多态性与铂类化疗疗效显著相关（OR=0.38, P=0.049）。rs3740051、rs12778366的遗传多态性与铂类化疗疗效之间无显著相关性。结论 SIRT1 rs3758391基因多态性可以显著影响肺癌患者铂类化疗的敏感性，SIRT1可能作为肺癌铂类化疗疗效评估的标志物。
목적：탐토SIRT1기인다태성여폐암대이박류위기출적화료민감성적관계。방법선취338명폐암환자（기중184명대화료내약화154명대화료민감）위연구대상，소유환자균접수이박류（순박、잡박）위기출적화료。분석기SIRT1적소유단핵감산다태성，최후사선출4개tag SNPs진행기인분형。OR화CI용래평고SIRT1기인다태성여폐암환자화료효과적상관성。결과재>60세적폐암환자중，rs3758391적기인다태성여박류화료료효현저상관（OR=0.38, P=0.049）。rs3740051、rs12778366적유전다태성여박류화료료효지간무현저상관성。결론 SIRT1 rs3758391기인다태성가이현저영향폐암환자박류화료적민감성，SIRT1가능작위폐암박류화료료효평고적표지물。
Objective To explore the relationship between the SIRT1 genetic polymorphisms and chemosensitivity to plati-num-based chemotherapy in lung cancer patients. Methods A total of 338 lung cancer patients (184 resistant and 154 sensitive) were selected and treated by platinum-based chemotherapy in this study. All single nucleotide polymorphisms in SIRT1 gene were analyzed and four tagging SNPs were final y screened for genotyped. The odds ratios (OR) with 95%confidence intervals (CI) were used to assess the effect of SIRT1 Genes Polymorphisms on the chemosensitivity of patients with lung cancer. Results We found a significant association of SIRT1 rs3758391 polymorphism with platinum-based chemotherapy effectiveness in lung cancer patients who were older than 60 years (OR=0.38, P=0.049). While no significant correlation was discovered between rs3740051, rs12778366 genetic polymorphism and platinum-based chemotherapy effect . Conclusion Our findings suggest that the SIRT1 rs3758391 genetic polymorphism can affect platinum-based chemotherapy sensitivity in lung cancer patients, and SIRT1 may be act as a potential biomarker on lung cancer chemotherapy response.