CAJ | 학술논문

背景：遗传多态性短串联重复序列（short tandem repeats, STRs）分析是用于检测基因型和表型之间关联的公认方法,但它以前没有在冲动攻击行为的遗传学研究中使用。 　　目的：在有冲动攻击行为史的男性和无冲动攻击行为史的男性对照组之间,比较15个STR基因位点(D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818和FGA)不同多态性的发生率。 　　方法：应用AmpFlSTR?Identifiler?试剂盒比较407个有冲动性攻击行为的案例和415个对照的15个STR基因位点等位基因的分布。 　　结果：有冲动攻击行为史的男性以下等位基因的平均频率显著低于对照组：TH01的等位基因10(OR=0.29,95%CI=0.16-0.52, p<0.0001), TPOX的等位基因8(OR=0.71,95%CI=0.58-0.86, p=0.0005), TPOX的等位基因9(OR=0.65,95%CI=0.47-0.89, p=0.0072),和CSF1PO的等位基因14(OR=0.27,95%CI=0.11-0.68, p=0.0035)。而案例组有一个等位基因频率显著高于对照组：TPOX的等位基因11(OR=1.79,95%CI=1.45-2.22, p<0.0001)。 　　结论：据我们所知，本项行为遗传学研究首次清楚表明了特定的遗传标记与非精神病罪犯的冲动暴力行为之间的密切关系。进一步的前瞻性工作将需要确定已辨识出的等位基因是否可以被认为是冲动攻击行为的危险因素以及导致这种关系的基本机制。
배경：유전다태성단천련중복서렬（short tandem repeats, STRs）분석시용우검측기인형화표형지간관련적공인방법,단타이전몰유재충동공격행위적유전학연구중사용。 　　목적：재유충동공격행위사적남성화무충동공격행위사적남성대조조지간,비교15개STR기인위점(D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818화FGA)불동다태성적발생솔。 　　방법：응용AmpFlSTR?Identifiler?시제합비교407개유충동성공격행위적안례화415개대조적15개STR기인위점등위기인적분포。 　　결과：유충동공격행위사적남성이하등위기인적평균빈솔현저저우대조조：TH01적등위기인10(OR=0.29,95%CI=0.16-0.52, p<0.0001), TPOX적등위기인8(OR=0.71,95%CI=0.58-0.86, p=0.0005), TPOX적등위기인9(OR=0.65,95%CI=0.47-0.89, p=0.0072),화CSF1PO적등위기인14(OR=0.27,95%CI=0.11-0.68, p=0.0035)。이안례조유일개등위기인빈솔현저고우대조조：TPOX적등위기인11(OR=1.79,95%CI=1.45-2.22, p<0.0001)。 　　결론：거아문소지，본항행위유전학연구수차청초표명료특정적유전표기여비정신병죄범적충동폭역행위지간적밀절관계。진일보적전첨성공작장수요학정이변식출적등위기인시부가이피인위시충동공격행위적위험인소이급도치저충관계적기본궤제。
Background:Analysis of genetic polymorphisms in short tandem repeats (STRs) is an accepted method for detecting associations between genotype and phenotype but it has not previously been used in the study of the genetics of impulsive violent behavior. Objective:Compare the prevalence of different polymorphisms in 15 STR loci (D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818 and FGA) between men with a history of impulsive violence and male control subjects without a history of impulsive violence. Methods:The distributions of the alleles of the 15 STR loci were compared between 407 cases with impulsive violent behavior and 415 controls using AmpFlSTR? Identifiler?kits. Results:Compared to controls, the average frequencies of the following alleles were significantly lower in individuals with a history of violent behavior:allele 10 of TH01 (OR=0.29, 95%CI=0.16-0.52, p<0.0001,), allele 8 of TPOX (OR=0.71, 95%CI=0.58-0.86, p=0.0005), allele 9 of TPOX (OR=0.65, 95%CI=0.47-0.89, p=0.0072) and allele 14 of CSF1PO (OR=0.27, 95%CI=0.11-0.68, p=0.0035). One allele was significantly higher in cases than controls:allele 11 of TPOX (OR=1.79, 95%CI=1.45-2.22, p<0.0001). Conclusions:To the best of our knowledge, this is the first behavioral genetic study that clearly demonstrates a close relationship between specific genetic markers and impulsive aggression in non-psychiatric offenders. Further prospective work will be needed to determine whether or not the alleles identified can be considered risk factors for impulsive aggression and, if so, the underlying mechanisms that result in this relationship.