CAJ | 학술논문

丙型肝炎病毒（HCV）具有较高的变异性，通常以准种的形式分布在感染者的体内，病毒容易逃离机体的免疫监控，因而无法被有效地清除，导致机体很难控制其感染的发展，故易转变成慢性肝炎。HCV准种变异在宿主体内的持续存在对病毒感染的控制、抗病毒药物和疫苗的发展都是一个巨大的挑战。我们重点阐述近年来关于HCV准种变异及其与慢性丙型肝炎患者的机体免疫、疾病进展、治疗效果之间关系的研究进展。
병형간염병독（HCV）구유교고적변이성，통상이준충적형식분포재감염자적체내，병독용역도리궤체적면역감공，인이무법피유효지청제，도치궤체흔난공제기감염적발전，고역전변성만성간염。HCV준충변이재숙주체내적지속존재대병독감염적공제、항병독약물화역묘적발전도시일개거대적도전。아문중점천술근년래관우HCV준충변이급기여만성병형간염환자적궤체면역、질병진전、치료효과지간관계적연구진전。
Hepatitis C virus(HCV) has high variability and circulates in vivo as a quasispecies leading to chron-ic hepatitis C infection which is difficult to control. HCV easily lead to virus escape from immune surveillance, and thus can not be effectively removed. The large reservoir of variants provided by the quasispecies represents a great challenge for the control of HCV infection and has important biologic implication for viral persistence, host cell tropism, antiviral drug resistance, and development of an HCV vaccine. In this review we discussed the rele-vance of the HCV quasispecies variability to immune response, disease progression and response to therapy.