CAJ | 학술논문

作为一类具有独特构效关系的细胞周期非特异性抗肿瘤药物，顺铂在临床治疗卵巢癌、前列腺癌、睾丸癌等实体肿瘤中显示了良好的疗效。然而，经典顺铂类抗肿瘤药物结构上的相似性使得耐药性或交叉耐药性成为限制该类药物临床应用的主要障碍之一。通过对经典铂类抗肿瘤药物耐药机制的研究和探讨，不仅可以指导已上市铂类药物的临床使用，而且能够有效地针对其耐药机制的产生来进行更为合理的药物设计和结构修饰改造，从而获得具有更好疗效、更低毒副作用的新型铂类抗肿瘤药物。
작위일류구유독특구효관계적세포주기비특이성항종류약물，순박재림상치료란소암、전렬선암、고환암등실체종류중현시료량호적료효。연이，경전순박류항종류약물결구상적상사성사득내약성혹교차내약성성위한제해류약물림상응용적주요장애지일。통과대경전박류항종류약물내약궤제적연구화탐토，불부가이지도이상시박류약물적림상사용，이차능구유효지침대기내약궤제적산생래진행경위합리적약물설계화결구수식개조，종이획득구유경호료효、경저독부작용적신형박류항종류약물。
As a class of cell cycle non -specific anticancer drugs with a unique structure -activity,Cisplatin shows good efficacy in the clinical treatment of ovarian cancer,prostate cancer,testicular cancer and other solid tumors.However,resistance or cross-resistance of the cisplatin analogous is becoming one of the main obstacles for cisplatin and its analogous,which limits their clinical applications.Understanding the resistance mechanisms of the classic platinum-based anticancer drugs not only helps doctors in clinical applications,but also gives us more targeted information in rational drug design to obtain novel platinum-based drugs with better efficacy and lower toxicity.This paper reviews research progress of the classic cisplatin analgous for their drug resistance mechanisms.