CAJ | 학술논문

非动脉炎性前部缺血性视神经病变(NAION)是引起中老年人视功能严重损害的常见视神经疾病,目前其发病机制尚不完全清楚,因此治疗效果并不理想,NAION的实验研究成为该病预防和治疗的方向,而建立较为理想的实验动物模型(包括啮齿类和灵长类动物)的研究已成为研究热点.近年来,NAION动物模型的建立方法不断进步,应用光动力学的方法成功建立的NAION模型使人们对该病的病理生理机制有了更加深入的了解,也为探索有效的治疗方法奠定了基础.就NAION动物模型制备过程中的实验动物选择、不同造模方法以及存在的问题进行分析综述,为进一步的实验研究提供参考.
비동맥염성전부결혈성시신경병변(NAION)시인기중노년인시공능엄중손해적상견시신경질병,목전기발병궤제상불완전청초,인차치료효과병불이상,NAION적실험연구성위해병예방화치료적방향,이건립교위이상적실험동물모형(포괄교치류화령장류동물)적연구이성위연구열점.근년래,NAION동물모형적건립방법불단진보,응용광동역학적방법성공건립적NAION모형사인문대해병적병리생리궤제유료경가심입적료해,야위탐색유효적치료방법전정료기출.취NAION동물모형제비과정중적실험동물선택、불동조모방법이급존재적문제진행분석종술,위진일보적실험연구제공삼고.
Nonarteritic anterior ischemic optic neuropathy (NAION)is a common optic neuropathy seriously affecting the visual function in the middle-aged and elderly population.However,its pathogenesis is not completely clear,and therefore its treating efficacy is dissatisfactory.The current study on NAION is focused on the establishment of suitable animal model and the pathogenesis.In recent years,the relatively ideal animal models(including rodent and primate) have been established by photodynamic methods,which make people have more in-depth understanding on the pathophysiologic mechanism of NAION and lay the basis for the research of therapies.The selection of experimental animals,various induction methods and existing problems in the creation of NAION animal model were reviewed and analyzed in this artical.