CAJ | 학술논문

目的：探讨重型妊娠期急性脂肪肝的诊断和治疗，降低孕产妇及围生儿病死率。方法对2例重型妊娠期急性脂肪肝患者的临床资料进行回顾性分析。结果2例患者均于孕晚期出现不同程度消化道症状，主要表现为恶心、口干等，出现皮肤黄染，伴凝血功能障碍、肝肾功能损伤及多脏器功能衰竭等；实验室检查可见血清转氨酶、胆红素升高，血小板下降，凝血酶原时间、活化部分凝血活酶时间延长，纤维蛋白原降低，胎儿监护提示胎儿宫内窘迫等特征。结论重视妊娠晚期无诱因的消化道症状，及时进行血清转氨酶及胆红素等实验室检查，早期诊断、尽快终止妊娠能提高母儿生存率。
목적：탐토중형임신기급성지방간적진단화치료，강저잉산부급위생인병사솔。방법대2례중형임신기급성지방간환자적림상자료진행회고성분석。결과2례환자균우잉만기출현불동정도소화도증상，주요표현위악심、구간등，출현피부황염，반응혈공능장애、간신공능손상급다장기공능쇠갈등；실험실검사가견혈청전안매、담홍소승고，혈소판하강，응혈매원시간、활화부분응혈활매시간연장，섬유단백원강저，태인감호제시태인궁내군박등특정。결론중시임신만기무유인적소화도증상，급시진행혈청전안매급담홍소등실험실검사，조기진단、진쾌종지임신능제고모인생존솔。
Objective To study the clinical diagnosis and treatment of heavy acute fatty liver of pregnancy ( AFLP) ,and to decrease the fatality rate of pregnant and lying-in women and perinatal fetus.Methods The clinical data of 2 cases of AFLP patients were retrospectively analyzed.Results All of the 2 cases showed varying de-grees of gastrointestinal symptoms in late pregnancy.The main clinical symptoms were nausea,dry mouth,skin stained yellow,coagulation disorders,liver and kidney function damage and multiple organ failure.Laboratory examination showed transaminase and bilirubin lift,decrease of platelet,Prothrombin time and activated partial thromboplastin time be extended,fibrinogen decreased,and fetal monitoring revealed fetal distress,and so on.Conclusion Pay attention to the unprovoked gastrointestinal symptoms in late pregnancyand,detects timely laboratory tests like serum transaminase and bilirubin .Early diagnosis、to timely termination of pregnancy can improve ma-ternal and fetal survival rate.