CAJ | 학술논문

目的：探讨E-cadherin及Survivin在不同临床病理学类型胃癌中的表达及二者的相关性，分析它们在胃癌发生、浸润及转移中的作用，为胃癌诊治和判断预后提供依据。方法采用免疫组化法（S-P法），检测E-cadherin、Survivin在胃癌及癌旁组织中的表达，分析它们与胃癌各临床病理特征之间的关系。结果（1）胃癌组织中E-cadherin阳性表达率低于癌旁正常黏膜组织，Survivin阳性表达率高于癌旁正常黏膜组织（P均＜0.01）。（2）胃癌组织 E-cadherin 表达与胃癌分化程度、浸润深度、淋巴结转移及远处转移显著相关（P＜0.05或0.01），Survivin表达与胃癌浸润深度、淋巴结转移、远处转移及 TNM分期显著相关（P＜0.05或0.01）。（3）胃癌组织中，E-cadherin和Survivin表达呈明显负相关性（r＝-0.504， P＜0.01）。结论（1）E-cadherin、Survivin 表达异常参与了胃癌发生发展过程，可作为检测早期胃癌的一个生物学标志。（2）E-cadherin、Survivin在胃癌中表达异常可导致胃癌细胞更具侵袭性，易于转移，可作为预测胃癌进展和预后的指标。（3）在胃癌中，E-cadherin与Survivins阳性表达呈负相关性，提示二者在胃癌的发生发展过程中可能存在一定关系。
목적：탐토E-cadherin급Survivin재불동림상병이학류형위암중적표체급이자적상관성，분석타문재위암발생、침윤급전이중적작용，위위암진치화판단예후제공의거。방법채용면역조화법（S-P법），검측E-cadherin、Survivin재위암급암방조직중적표체，분석타문여위암각림상병리특정지간적관계。결과（1）위암조직중E-cadherin양성표체솔저우암방정상점막조직，Survivin양성표체솔고우암방정상점막조직（P균＜0.01）。（2）위암조직 E-cadherin 표체여위암분화정도、침윤심도、림파결전이급원처전이현저상관（P＜0.05혹0.01），Survivin표체여위암침윤심도、림파결전이、원처전이급 TNM분기현저상관（P＜0.05혹0.01）。（3）위암조직중，E-cadherin화Survivin표체정명현부상관성（r＝-0.504， P＜0.01）。결론（1）E-cadherin、Survivin 표체이상삼여료위암발생발전과정，가작위검측조기위암적일개생물학표지。（2）E-cadherin、Survivin재위암중표체이상가도치위암세포경구침습성，역우전이，가작위예측위암진전화예후적지표。（3）재위암중，E-cadherin여Survivins양성표체정부상관성，제시이자재위암적발생발전과정중가능존재일정관계。
Objective To analyze the role of E-cadherin and Survivin in gastric cancer occurrence and development. Methods Expressions of E-cadherin and Survivin in gastric carcinoma specimens were detected by immunohistochemistry S-P, and their correlation with characteristics of clinical materials were evaluated. Results The positive rates of E-cadherin were significantly lower than that in adjacent normal gastric mucosa(P<0.01) while the positive rates of Survivin were significantly higher than that in adjacent normal gastric mucosa(P<0.01). The expression of E-cadherin in gastric carcinoma was significantly correlated with its differentiation, depth of invasion, lymph node metastasis, and distant metastasis(P<0.05 or 0.01). The expression of E-cadherin in gastric carcinoma was significantly correlated with its depth of invasion, lymph node metastasis, distant metastasis and tumor TNM stages(P<0.05 or 0.01). The difference between the expression of E-cadherin and Survivin was significantly correlated in gastric cancers(χ2=20.554, P<0.01). The expression of E-cadherin was negative correlated with the expression of Survivin in gastric cancer(r=-0.504, P<0.01). Conclusions Abnormal expression of E-cadherin and Survivin could be involved in the occurrence and progress of gastric cancer, and they could to be useful markers for detecting early gastric cancer. Abnomal expression of E-cadherin or Survivin in gastric cancer correlated with increased invasiveness, then metastasis may occurred. The expression of E-cadherin was negative correlated with the expression of Survivin in gastric cancer, which indicated that the expression of E-cadherin and Survivin protein had some synergistic effect in the tumorigenesis and progression of gastric carcinoma.