中南大学学报（医学版）
中南大學學報（醫學版）
중남대학학보（의학판）
JOURNAL OF CENTRAL SOUTH UNIVERSITY (MEDICAL SCIENCES)
2013年
12期
1260-1263
,共4页
成平%夏运成%彭灿辉%周志芳
成平%夏運成%彭燦輝%週誌芳
성평%하운성%팽찬휘%주지방
唾液%尿素%肌酐%尿酸%终末期肾病%血液透析
唾液%尿素%肌酐%尿痠%終末期腎病%血液透析
타액%뇨소%기항%뇨산%종말기신병%혈액투석
saliva%urea%creatinine%uric acid%end-stage renal disease%hemodialysis
目的：探讨终末期肾病(ESRD)患者血液透析前后唾液尿素(Urea)、肌酐(Cr)、尿酸(UA)水平的变化，评估透析后Urea，Cr，UA的清除效果及临床应用价值。方法：收集透析患者的唾液2 mL，同时抽取动脉血2 mL，在全自动生化分析仪上测定血清和唾液Urea，Cr，UA的含量。比较透析前后血清与唾液Urea，Cr，UA浓度，分析其相关性，计算透析前后唾液和血清Urea，Cr，UA的下降比率(RR)。结果：透析患者血清与唾液Urea，Cr，UA水平高度相关(相关系数分别为0.909，0.873，0.901)。透析后血清和唾液中Urea，Cr，UA浓度比透析前显著降低(均P<0.05)。血清与唾液Urea，Cr，UA的RR值比较，差异无统计学意义(均P>0.05)。结论：ESRD透析患者唾液Urea，Cr，UA的清除效果与血清高度一致，有望替代血清Urea，Cr，UA水平来评估血液透析效果和监测患者肾功能。
目的：探討終末期腎病(ESRD)患者血液透析前後唾液尿素(Urea)、肌酐(Cr)、尿痠(UA)水平的變化，評估透析後Urea，Cr，UA的清除效果及臨床應用價值。方法：收集透析患者的唾液2 mL，同時抽取動脈血2 mL，在全自動生化分析儀上測定血清和唾液Urea，Cr，UA的含量。比較透析前後血清與唾液Urea，Cr，UA濃度，分析其相關性，計算透析前後唾液和血清Urea，Cr，UA的下降比率(RR)。結果：透析患者血清與唾液Urea，Cr，UA水平高度相關(相關繫數分彆為0.909，0.873，0.901)。透析後血清和唾液中Urea，Cr，UA濃度比透析前顯著降低(均P<0.05)。血清與唾液Urea，Cr，UA的RR值比較，差異無統計學意義(均P>0.05)。結論：ESRD透析患者唾液Urea，Cr，UA的清除效果與血清高度一緻，有望替代血清Urea，Cr，UA水平來評估血液透析效果和鑑測患者腎功能。
목적：탐토종말기신병(ESRD)환자혈액투석전후타액뇨소(Urea)、기항(Cr)、뇨산(UA)수평적변화，평고투석후Urea，Cr，UA적청제효과급림상응용개치。방법：수집투석환자적타액2 mL，동시추취동맥혈2 mL，재전자동생화분석의상측정혈청화타액Urea，Cr，UA적함량。비교투석전후혈청여타액Urea，Cr，UA농도，분석기상관성，계산투석전후타액화혈청Urea，Cr，UA적하강비솔(RR)。결과：투석환자혈청여타액Urea，Cr，UA수평고도상관(상관계수분별위0.909，0.873，0.901)。투석후혈청화타액중Urea，Cr，UA농도비투석전현저강저(균P<0.05)。혈청여타액Urea，Cr，UA적RR치비교，차이무통계학의의(균P>0.05)。결론：ESRD투석환자타액Urea，Cr，UA적청제효과여혈청고도일치，유망체대혈청Urea，Cr，UA수평래평고혈액투석효과화감측환자신공능。
Objective:To explore the changes of saliva urea, creatinine (Cr), and uric acid (UA) before and after hemodialysis in patients with end-stage renal disease (ESRD), and to evaluate the clearing effect of Urea, Cr, and UA. <br> Methods:Saliva and serum (2 mL) were collected from the dialysis patients. The concentrations of Urea, Cr, and UA in both samples were measured by biochemical analyzer. The concentrations of Urea, Cr, and UA in the saliva and the serum, and their correlation were analyzed. Before and after the hemodialysis, the reduction ratio (RR) of Urea, Cr, and UA in the saliva and the serum was calculated. <br> Results:In ESRD dialysis patients, the levels of Urea, Cr, and UA in the saliva and the serum were highly correlated (correlation coeffcients were 0.979, 0.973, and 0.948, respectively). The concentrations of Urea, Cr, and UA in the saliva and the serum before the dialysis were lower than those after the dialysis, with signiifcant difference (P<0.05). The RR of Urea, Cr, and UA in the saliva and the serum did not differ statistically (P>0.05). <br> Conclusion:The clearing effect of salivar Urea, Cr, and UA is similar to that of the serum. Saliva is expected to replace the serum to evaluate hemodialysis efficacy and monitor the renal disease in ESRD patients.
