CAJ | 학술논문

目的：探讨转化生长因子-β1( TGF-β1)和肿瘤坏死因子-α( TNF-α)与矽肺发病的关系。方法采用ELISA法对50名某酒店服务人员的对照人群，50名接触矽尘1年以上的接尘工人，32名矽尘作业观察对象及52例矽肺患者诱导痰中的TGF-β1和TNF-α的含量进行测定。结果与对照组(7.81±2.13)pg/mL比较，接尘组、观察对象组和矽肺组TNF-α水平(49.82±15.42)、(112.13±32.19)、(227.36±52.31)pg/mL 明显升高，差异有高度统计学意义(P＜0.01)；与接尘组(49.82±15.42)pg/mL比较，观察对象组和矽肺组TNF-α(112.13±32.19)、(227.36±52.31)pg/mL水平明显升高，差异有统计学意义(P＜0.05，P＜0.01)。与对照组(24.12±13.14)pg/mL和接尘组(28.42±15.56)pg/mL比较，观察对象组和矽肺组TGF-β1水平(48.21±16.45)、(61.34±30.22)pg/mL明显升高，差异有统计学意义(P＜0.05，P＜0.01)。结论 TGF-β1、TNF-α在矽肺发生发展中有重要作用，诱导痰中TGF-β1、TNF-α含量可以反映矽尘所致的肺组织炎症反应。
목적：탐토전화생장인자-β1( TGF-β1)화종류배사인자-α( TNF-α)여석폐발병적관계。방법채용ELISA법대50명모주점복무인원적대조인군，50명접촉석진1년이상적접진공인，32명석진작업관찰대상급52례석폐환자유도담중적TGF-β1화TNF-α적함량진행측정。결과여대조조(7.81±2.13)pg/mL비교，접진조、관찰대상조화석폐조TNF-α수평(49.82±15.42)、(112.13±32.19)、(227.36±52.31)pg/mL 명현승고，차이유고도통계학의의(P＜0.01)；여접진조(49.82±15.42)pg/mL비교，관찰대상조화석폐조TNF-α(112.13±32.19)、(227.36±52.31)pg/mL수평명현승고，차이유통계학의의(P＜0.05，P＜0.01)。여대조조(24.12±13.14)pg/mL화접진조(28.42±15.56)pg/mL비교，관찰대상조화석폐조TGF-β1수평(48.21±16.45)、(61.34±30.22)pg/mL명현승고，차이유통계학의의(P＜0.05，P＜0.01)。결론 TGF-β1、TNF-α재석폐발생발전중유중요작용，유도담중TGF-β1、TNF-α함량가이반영석진소치적폐조직염증반응。
Objective To investigate the relationship between transforming growth factor-β1 (TGF-β1 ),tumornecrosis factor-α(TNF-α) and the incidence of silicosis.Methods Fifty hotel staff were chosen as the control group,50 workers with more than one year of silica dust exposure,32 silica dust observed objects,and 52 silicosis patients as dust exposure group,dust observed group,silicosis patient group respectively to detect TGF-β1 and TNF-α levels in their induced sputum with ELISA method .Results Compared with the control group (7 .81±2 .13 )pg/mL,TNF-α (49 .82±15 .42 ),(112 .13±32 .19 ),(227 .36±52 .31 )pg/mL in dust exposure group,observed group and silicosis patient group increased significantly,and the difference was of high statistical significance(P<0. 01).Compared with the dust exposure group(49.82±15.42)pg/mL,TNF-α(112.13± 32.19),(227.36±52.31)pg/mL in observed group and silicosis patient group increased significantly, and the difference was of statistical significance(P<0.05,P<0.01).Compared with the control group(24.12±13.14) pg/mL and dust exposure group (28.42 ±15.56) pg/mL,TGF-β1 in observed group and silicosis patient group (48.21±16.45),(61.34 ±30.22) pg/mL increased significantly,and the difference was of statistical significance(P<0 .05,P<0. 01).Conclusion TGF-β1 and TNF-α have an im portant role in the developm ent of silicosis,and the content of TGF-β1 and TNF-αin induced sputum may reflect the lung tissue inflam mation caused by silica dust.