大理学院学报
大理學院學報
대이학원학보
JOURNAL OF DALI COLLEGE
2013年
12期
23-26
,共4页
重组人脑利钠肽%急性心力衰竭%脑钠肽%射血分数
重組人腦利鈉肽%急性心力衰竭%腦鈉肽%射血分數
중조인뇌리납태%급성심력쇠갈%뇌납태%사혈분수
recombinant human brain natriuretic peptide%acute heart failure%brain natriuretie peptide%ejection fraction
目的：探讨在监测血清脑钠肽水平下，短期使用注射用重组人脑利钠肽治疗急性心力衰竭或慢性心力衰竭急性发作的临床效果。方法：48例急性心力衰竭患者根据是否使用注射用重组人脑利钠肽分为常规组和注射用重组人脑利钠肽组，对比两组治疗的临床效果和超声心动图情况，并监测BNP水平。结果：治疗7 d后，注射用重组人脑利钠肽组临床有效率明显好于常规组（81.7%vs61.6%，P＜0.05），左室射血分数明显高于常规组（51±6）%vs（46±5）%，（P＜0.01），且血清脑钠肽水平明显降低（498±209）pg/mL vs（642±318）pg/mL，（P＜0.01），血清脑钠肽下降水平和左室射血分数提高水平差异有统计学意义（P＜0.05），有效者治疗后左室射血分数提高及血清脑钠肽下降均强于无效者（P＜0.01）。结论：在血清脑钠肽指导下短期应用注射用重组人脑利钠肽有助于改善急性心力衰竭患者的临床症状和心功能。
目的：探討在鑑測血清腦鈉肽水平下，短期使用註射用重組人腦利鈉肽治療急性心力衰竭或慢性心力衰竭急性髮作的臨床效果。方法：48例急性心力衰竭患者根據是否使用註射用重組人腦利鈉肽分為常規組和註射用重組人腦利鈉肽組，對比兩組治療的臨床效果和超聲心動圖情況，併鑑測BNP水平。結果：治療7 d後，註射用重組人腦利鈉肽組臨床有效率明顯好于常規組（81.7%vs61.6%，P＜0.05），左室射血分數明顯高于常規組（51±6）%vs（46±5）%，（P＜0.01），且血清腦鈉肽水平明顯降低（498±209）pg/mL vs（642±318）pg/mL，（P＜0.01），血清腦鈉肽下降水平和左室射血分數提高水平差異有統計學意義（P＜0.05），有效者治療後左室射血分數提高及血清腦鈉肽下降均彊于無效者（P＜0.01）。結論：在血清腦鈉肽指導下短期應用註射用重組人腦利鈉肽有助于改善急性心力衰竭患者的臨床癥狀和心功能。
목적：탐토재감측혈청뇌납태수평하，단기사용주사용중조인뇌리납태치료급성심력쇠갈혹만성심력쇠갈급성발작적림상효과。방법：48례급성심력쇠갈환자근거시부사용주사용중조인뇌리납태분위상규조화주사용중조인뇌리납태조，대비량조치료적림상효과화초성심동도정황，병감측BNP수평。결과：치료7 d후，주사용중조인뇌리납태조림상유효솔명현호우상규조（81.7%vs61.6%，P＜0.05），좌실사혈분수명현고우상규조（51±6）%vs（46±5）%，（P＜0.01），차혈청뇌납태수평명현강저（498±209）pg/mL vs（642±318）pg/mL，（P＜0.01），혈청뇌납태하강수평화좌실사혈분수제고수평차이유통계학의의（P＜0.05），유효자치료후좌실사혈분수제고급혈청뇌납태하강균강우무효자（P＜0.01）。결론：재혈청뇌납태지도하단기응용주사용중조인뇌리납태유조우개선급성심력쇠갈환자적림상증상화심공능。
Objective:To observe the clinic efficacy and safety of used recombinant human brain natriuretie peptide (rh-BNP)on patients with acute decompensated heart failure.Methods:48 patients who suffered from acute decompensated heart failure patients were divided into rh-BNP group(n=22)and control group(n=26).The rh-BNP group received rh-BNP made by China and traditional heart failure treatment; the control group was treated with traditional heart failure treatment.The changes of the clinical efficacy, left ventricular ejection fraction (LVEF)and brain natriuretie peptide test parameters were observed. Results:After 7 days treatment, clinical efficacy improvements were more significant in rh-BNP group compared control group (81.7% vs 61.6,P<0.05).LVEF were improved in rh-BNP group compared with control group((51±6)%vs(46±5)%,P<0.01).and BNP level were decreased obviously in rh-BNP group than control group((498±209)pg/ml vs(642±318)pg/ml,P<0.01),and there had positive relation in BNP decrease and LVEF increased(P<0.05).Conclusion:The use of rh-BNP is efficient and safe for acute decompensated heart failure patient.And BNP test can provide a dog marker for diagnosis and prognostic.
