国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2013年
1期
109-111
,共3页
慢性阻塞性肺疾病%肿瘤坏死因子%白细胞介素-8%变化
慢性阻塞性肺疾病%腫瘤壞死因子%白細胞介素-8%變化
만성조새성폐질병%종류배사인자%백세포개소-8%변화
COPD%TNF-α%IL-8%Changes
目的 探讨COPD患者急性发作期血清肿瘤坏死因子(TNF-α)和白细胞介素-8(IL-8)水平变化的意义.方法 回顾性分析2009至2012年我院收治的80例急性发作期的COPD患者,分为对照组和实验组.对照组为非呼吸衰竭组,实验组为呼吸衰竭组.采用放射免疫分析法(RIA)测定其血清TNF-α和IL-8水平进行比较,并检测其呼吸功能,探究其中的相关性.结果 实验组TNF-α和IL-8的血清含量均高于对照组,差异有显著性(P＜0.05).实验组FEV1％小于对照组,差异有显著性(P＜0.05).TNF-α和IL-8水平和患者的FEV1％呈负相关,相关系数分别为-0.72和-0.65(P＜ 0.05).结论 合并呼吸衰竭的COPD急性加重期患者同未合并呼吸衰竭的患者相比血清TNF-α和IL-8较高,TNF-α和IL-8的升高可能加重了COPD患者的气道阻塞,TNF-α和IL-8可以协助对患者的病情和预后进行监测.
目的 探討COPD患者急性髮作期血清腫瘤壞死因子(TNF-α)和白細胞介素-8(IL-8)水平變化的意義.方法 迴顧性分析2009至2012年我院收治的80例急性髮作期的COPD患者,分為對照組和實驗組.對照組為非呼吸衰竭組,實驗組為呼吸衰竭組.採用放射免疫分析法(RIA)測定其血清TNF-α和IL-8水平進行比較,併檢測其呼吸功能,探究其中的相關性.結果 實驗組TNF-α和IL-8的血清含量均高于對照組,差異有顯著性(P＜0.05).實驗組FEV1％小于對照組,差異有顯著性(P＜0.05).TNF-α和IL-8水平和患者的FEV1％呈負相關,相關繫數分彆為-0.72和-0.65(P＜ 0.05).結論 閤併呼吸衰竭的COPD急性加重期患者同未閤併呼吸衰竭的患者相比血清TNF-α和IL-8較高,TNF-α和IL-8的升高可能加重瞭COPD患者的氣道阻塞,TNF-α和IL-8可以協助對患者的病情和預後進行鑑測.
목적 탐토COPD환자급성발작기혈청종류배사인자(TNF-α)화백세포개소-8(IL-8)수평변화적의의.방법 회고성분석2009지2012년아원수치적80례급성발작기적COPD환자,분위대조조화실험조.대조조위비호흡쇠갈조,실험조위호흡쇠갈조.채용방사면역분석법(RIA)측정기혈청TNF-α화IL-8수평진행비교,병검측기호흡공능,탐구기중적상관성.결과 실험조TNF-α화IL-8적혈청함량균고우대조조,차이유현저성(P＜0.05).실험조FEV1％소우대조조,차이유현저성(P＜0.05).TNF-α화IL-8수평화환자적FEV1％정부상관,상관계수분별위-0.72화-0.65(P＜ 0.05).결론 합병호흡쇠갈적COPD급성가중기환자동미합병호흡쇠갈적환자상비혈청TNF-α화IL-8교고,TNF-α화IL-8적승고가능가중료COPD환자적기도조새,TNF-α화IL-8가이협조대환자적병정화예후진행감측.
Objective To explore the significance of changes in levels of TNF-α and IL-8 in acute exacerbation of COPD.Methods The data on 80 patients with acute exacerbation of COPD who had been hospitalized during the period of 2009 to 2011 were retrospectively analyzed.The patients were divided into two groups.The control group included 40 patients with respiratory failure; and the study group included 40 patients without respiratory failure.RIA was used to measure serum levels of TNF-α and IL-8; respiratory function was detected.The association of serum levels of TNF-α and IL-8 with respiratory function was determined.Results Levels of TNF-α and IL-8 were significantly higher in the study group than in the control group (P＜0.05).FEV1％ was significantly lower in the study group than in the control group (P＜0.05).Levels of TNF-α and IL-8 had a negative correlation with FEV1％,with a correlation coefficient of-0.72 and-0.65 (P＜0.05).Conclusions Patients with acute exacerbation of COPD complicated by respiratory failure have higher serum levels of TNF-α and IL-8 than those without respiratory failure.Increased levels of TNF-α and IL-8 may aggravate airway obstruction in COPD patients.TNF-α and IL-8 can help monitor disease severity and prognosis.
