中华临床医师杂志(电子版)
中華臨床醫師雜誌(電子版)
중화림상의사잡지(전자판)
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2013年
19期
8827-8830
,共4页
泛素化%NF-κB%SHARPIN%生物学功能
汎素化%NF-κB%SHARPIN%生物學功能
범소화%NF-κB%SHARPIN%생물학공능
Ubiquitination%NF-kappa B%SHARPIN%Biological function
人类线性泛素链相关蛋白SHARPIN在哺乳动物体内广泛存在,主要分布于大脑、心脏和睾丸等器官细胞的胞质内,可通过线性泛素化调节介导NF-κB信号通路激活等途径对机体产生多种生理效应,特别是在炎症和免疫系统的发展中可能起着重要的作用。另外,SHARPIN与肿瘤发生、发展、转归的关系更成为近年来研究的热点,目前发现在多种肿瘤中 SHARPIN 表达均升高,但机制尚未明确。本文就SHARPIN的分子结构、与机体多种疾病发生发展的相关机制展开综述,并对SHARPIN未来的研究方向进行展望。
人類線性汎素鏈相關蛋白SHARPIN在哺乳動物體內廣汎存在,主要分佈于大腦、心髒和睪汍等器官細胞的胞質內,可通過線性汎素化調節介導NF-κB信號通路激活等途徑對機體產生多種生理效應,特彆是在炎癥和免疫繫統的髮展中可能起著重要的作用。另外,SHARPIN與腫瘤髮生、髮展、轉歸的關繫更成為近年來研究的熱點,目前髮現在多種腫瘤中 SHARPIN 錶達均升高,但機製尚未明確。本文就SHARPIN的分子結構、與機體多種疾病髮生髮展的相關機製展開綜述,併對SHARPIN未來的研究方嚮進行展望。
인류선성범소련상관단백SHARPIN재포유동물체내엄범존재,주요분포우대뇌、심장화고환등기관세포적포질내,가통과선성범소화조절개도NF-κB신호통로격활등도경대궤체산생다충생리효응,특별시재염증화면역계통적발전중가능기착중요적작용。령외,SHARPIN여종류발생、발전、전귀적관계경성위근년래연구적열점,목전발현재다충종류중 SHARPIN 표체균승고,단궤제상미명학。본문취SHARPIN적분자결구、여궤체다충질병발생발전적상관궤제전개종술,병대SHARPIN미래적연구방향진행전망。
SHARPIN, related to the linear poly-ubiquitin chain, has been found in mammalian, resides in the cytoplasm of brains, hearts and testis. It can activate NF-κB signal pathway via linear poly-ubiquitination and conduct a broad range of physiological actions. More and more researches showed it might play important roles in inflammations and improvement of immune systems of SHARPIN. Moreover, it has been a subject on the effects of SHARPIN on the occurrence, development, and transformation of tumors, there are some evidences showing higher expression of SHARPIN in some tumor tissues. The review aims at exhibiting the molecular structures, mechanisms on diseases, and looks forward to its future development.