中华临床医师杂志(电子版)
中華臨床醫師雜誌(電子版)
중화림상의사잡지(전자판)
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2013年
19期
8701-8706
,共6页
於文达%范阜东%张杰%王东进
於文達%範阜東%張傑%王東進
어문체%범부동%장걸%왕동진
左心房内径%左心房重塑%左心房逆向重塑%二尖瓣手术%二尖瓣成形
左心房內徑%左心房重塑%左心房逆嚮重塑%二尖瓣手術%二尖瓣成形
좌심방내경%좌심방중소%좌심방역향중소%이첨판수술%이첨판성형
Left atrial diameter%Left atrial remodeling%Left atrial reverse remodeling%Mitral valve surgery
目的:左心房内径(LAD)是一个重要的心血管事件预测因子,二尖瓣关闭不全患者术后产生左心房逆向重塑。拟探讨退行性二尖瓣关闭不全术后左心房逆向重塑的预测因素。方法回顾性分析2007年6月至2012年6月我科收治并经筛选的111例退行性二尖瓣病变患者临床资料、术前及术后早期超声数据。男67例,女44例,平均年龄(47±18)岁。70例行二尖瓣成形,41例行二尖瓣置换术。依据年龄, LAD与人体表面积的比值(LADi),术前二尖瓣关闭不全分型,手术类型,术前心律和有无人工瓣环植入等行统计分析。结果术后LADi改变[术前(2.83±0.64)cm/m2 vs.术后(2.32±0.51)cm/m2,P<0.001]。术后LAD改变[术前(4.94±0.96)cm vs.术后(4.06±0.83)cm,P<0.001]。左心房逆向重塑更明显地体现在<50岁的病例中(LADi改变程度:-26.56%±12.92% vs.-20.95%±13.01%,P=0.025)以及术前LADi≥2.6 cm/m2的病例(LADi改变程度:-29.16%±11.37%vs.-17.57%±12.51%,P<0.001)。术后LADi改变程度的关联指标为术前LADi(P<0.001),术前LAD(P=0.007),体表面积(P<0.001),术前LVEF(P=0.015)和年龄(P=0.030)。通过多元回归分析,术前LADi,体表面积和术前LVEF是术后左心房逆向重塑的重要预测因子。结论术前 LADi 是二尖瓣关闭不全术后左心房逆向重塑的重要预测因子,年轻患者和术前LAD较大的患者术后左心房逆向重塑更为显著。
目的:左心房內徑(LAD)是一箇重要的心血管事件預測因子,二尖瓣關閉不全患者術後產生左心房逆嚮重塑。擬探討退行性二尖瓣關閉不全術後左心房逆嚮重塑的預測因素。方法迴顧性分析2007年6月至2012年6月我科收治併經篩選的111例退行性二尖瓣病變患者臨床資料、術前及術後早期超聲數據。男67例,女44例,平均年齡(47±18)歲。70例行二尖瓣成形,41例行二尖瓣置換術。依據年齡, LAD與人體錶麵積的比值(LADi),術前二尖瓣關閉不全分型,手術類型,術前心律和有無人工瓣環植入等行統計分析。結果術後LADi改變[術前(2.83±0.64)cm/m2 vs.術後(2.32±0.51)cm/m2,P<0.001]。術後LAD改變[術前(4.94±0.96)cm vs.術後(4.06±0.83)cm,P<0.001]。左心房逆嚮重塑更明顯地體現在<50歲的病例中(LADi改變程度:-26.56%±12.92% vs.-20.95%±13.01%,P=0.025)以及術前LADi≥2.6 cm/m2的病例(LADi改變程度:-29.16%±11.37%vs.-17.57%±12.51%,P<0.001)。術後LADi改變程度的關聯指標為術前LADi(P<0.001),術前LAD(P=0.007),體錶麵積(P<0.001),術前LVEF(P=0.015)和年齡(P=0.030)。通過多元迴歸分析,術前LADi,體錶麵積和術前LVEF是術後左心房逆嚮重塑的重要預測因子。結論術前 LADi 是二尖瓣關閉不全術後左心房逆嚮重塑的重要預測因子,年輕患者和術前LAD較大的患者術後左心房逆嚮重塑更為顯著。
목적:좌심방내경(LAD)시일개중요적심혈관사건예측인자,이첨판관폐불전환자술후산생좌심방역향중소。의탐토퇴행성이첨판관폐불전술후좌심방역향중소적예측인소。방법회고성분석2007년6월지2012년6월아과수치병경사선적111례퇴행성이첨판병변환자림상자료、술전급술후조기초성수거。남67례,녀44례,평균년령(47±18)세。70례행이첨판성형,41례행이첨판치환술。의거년령, LAD여인체표면적적비치(LADi),술전이첨판관폐불전분형,수술류형,술전심률화유무인공판배식입등행통계분석。결과술후LADi개변[술전(2.83±0.64)cm/m2 vs.술후(2.32±0.51)cm/m2,P<0.001]。술후LAD개변[술전(4.94±0.96)cm vs.술후(4.06±0.83)cm,P<0.001]。좌심방역향중소경명현지체현재<50세적병례중(LADi개변정도:-26.56%±12.92% vs.-20.95%±13.01%,P=0.025)이급술전LADi≥2.6 cm/m2적병례(LADi개변정도:-29.16%±11.37%vs.-17.57%±12.51%,P<0.001)。술후LADi개변정도적관련지표위술전LADi(P<0.001),술전LAD(P=0.007),체표면적(P<0.001),술전LVEF(P=0.015)화년령(P=0.030)。통과다원회귀분석,술전LADi,체표면적화술전LVEF시술후좌심방역향중소적중요예측인자。결론술전 LADi 시이첨판관폐불전술후좌심방역향중소적중요예측인자,년경환자화술전LAD교대적환자술후좌심방역향중소경위현저。
Objective Left atrial diameter(LAD) is an important predictor of outcome after mitral valve surgery in patients with mitral regurgitation (MR). This study aimed to investigate the factors determining early left atrial (LA) reverse remodeling after mitral valve (MV) surgery. Methods From 2007.06 to 2012.06, 111 patients [67 men, 44 women;aged (46.92±17.67)yrs] who underwent degenerative MV surgery(70 repair and 41 replacement) were reviewed. The percentage of LADi(LA Diameter indexed to Bodysurface area, cm/m2) change was calculated. The patients were grouped according to age(<50 yrs vs.≥50 yrs), LADi(<2.6 cm/m2 vs.≥2.6 cm/m2), predominant lesion (prolapsed anterior leaflet, prolapsed posterior leaflet, diseased bileaflet & other including commissural prolapsed, dialated mitral ring, etc), type of surgery(MV repair vs. MV replacement), preoperative cardiac rhythm (sinus rhythm vs. atrial fibrillation)and implantation of prosthetic ring, etc. Results LADi reduction percent decreased from (2.83±0.64)cm/m2 to (2.32±0.51)cm/m2 (P<0.001) after surgery.LAD Reduction decreased from (4.94±0.96)cm to (4.06±0.83)cm (P<0.001). LA reverse remodeling was more prominent in patients who were<50 yrs old(percentage of LADi reduction -26.56%± 12.92% vs. -20.95%± 13.01%, P=0.025), had LADi≥2.6 cm/m2 (percentage of LADi reduction -29.16%± 11.37% vs. -17.57%± 12.51%, P<0.001). Correlates of percentage of LADi reduction were preOpLADi(P<0.001), preOpLAD(P=0.007), bodysurface(P<0.001), preOpLVEF(P=0.015) and age(P=0.030). On stepwise multiple regression analysis, preoperative LADi, bodysurface and preOpLVEF were significant predictors of LA reverse remodeling. Conclusion Younger age and a larger preoperative LADi were important predictors of LA reverse remodeling after degenerative MV surgery.