CAJ | 학술논문

目的：分析及比较颅内外大动脉闭塞患者血常规和临床常用生化指标的变化。方法回顾分析了89例颈内动脉闭塞（internal carotid artery occlusion，ICAO）、74例大脑中动脉闭塞（middle cerebral artery occlusion，MCAO）和29例颈内动脉合并大脑中动脉闭塞（ICAO&MCAO）患者的血常规和临床常用生化指标，并与84例影像学除外颅内外大动脉闭塞的患者（对照组）进行比较。结果与对照组比较， MCAO 组及ICAO&MCAO组白细胞计数（white blood count，WBC）、闭塞组中性粒细胞比例（GR%）和血沉（erythrocyte sedimentation rate，ESR）明显增高，差异均有统计学意义（P＜0.05或0.01）。MCAO组高密度载脂蛋白（HDL-C）水平明显低于ICAO组和对照组（P＜0.05或0.01）；ICAO组低密度载脂蛋白（LDL-C）水平明显低于对照组（P＜0.05）。ICAO组血乳酸（LA）水平明显高于其他各组（P＜0.01）；MCAO 组 LA 水平亦明显高于对照组。ICAO&MCAO组血尿酸（UA）水平明显低于ICAO组和对照组，差异具有统计学意义（P＜0.01）；血糖（GLU）、总胆固醇和甘油三酯在各组比较中未见统计学差异。结论颅内外大动脉闭塞患者的 WBC、GR%和ESR明显增高，这可能提示炎症参与了颅内外大动脉闭塞的病理生理过程。而颅内外大动脉闭塞患者的 HDL-C、LDL-C、LA和UA水平亦可出现异常变化，其具体病理生理意义尚有待于进一步研究。
목적：분석급비교로내외대동맥폐새환자혈상규화림상상용생화지표적변화。방법회고분석료89례경내동맥폐새（internal carotid artery occlusion，ICAO）、74례대뇌중동맥폐새（middle cerebral artery occlusion，MCAO）화29례경내동맥합병대뇌중동맥폐새（ICAO&MCAO）환자적혈상규화림상상용생화지표，병여84례영상학제외로내외대동맥폐새적환자（대조조）진행비교。결과여대조조비교， MCAO 조급ICAO&MCAO조백세포계수（white blood count，WBC）、폐새조중성립세포비례（GR%）화혈침（erythrocyte sedimentation rate，ESR）명현증고，차이균유통계학의의（P＜0.05혹0.01）。MCAO조고밀도재지단백（HDL-C）수평명현저우ICAO조화대조조（P＜0.05혹0.01）；ICAO조저밀도재지단백（LDL-C）수평명현저우대조조（P＜0.05）。ICAO조혈유산（LA）수평명현고우기타각조（P＜0.01）；MCAO 조 LA 수평역명현고우대조조。ICAO&MCAO조혈뇨산（UA）수평명현저우ICAO조화대조조，차이구유통계학의의（P＜0.01）；혈당（GLU）、총담고순화감유삼지재각조비교중미견통계학차이。결론로내외대동맥폐새환자적 WBC、GR%화ESR명현증고，저가능제시염증삼여료로내외대동맥폐새적병리생리과정。이로내외대동맥폐새환자적 HDL-C、LDL-C、LA화UA수평역가출현이상변화，기구체병리생리의의상유대우진일보연구。
Objective To analysis the changes of blood routine test and some common biochemical indexes such as erythrocyte sedimentation rate (ESR), serum lipid levels, blood sugar, lactic acid and uric acid in patients with intracranial and extracranial arteries occlusive diseases. Methods This study retrospective studied the blood routine test and clinic common biochemical indexes of 89 patients with ICAO, 74 patients with MCAO, 29 patients with ICAO and MCAO, Which is compared with 84 patients with other types of ischemic cerebrovascular disease. Results Inflammatory biochemical indexes: compared with control group, GR% and ESR were higher in three intracranial and extracranial arteries occlusive groups(P<0.01); Meanwhile the same result were confirmed in MCAO group and ICAO & MCAO group for WBC level(P<0.05 or 0.01). Blood fat level:compared with ICAO group and control group, serum HDL-C was lower in MCAO group(P<0.05 or 0.01);and we got the same result for comparison with serum LDL-C in the ICAO group versus control group(P<0.05). Other indexes in each group were not statistically different. Other biochemical indexes:compared with other groups, serum LA were significantly higher in the ICAO groups(P<0.01);and we can see the same result in comparison for control group and ICAO group(P<0.01); While serum UA was lower in ICAO & MCAO group compared with ICAO group and control group(P<0.01), Glucose level in each group were not statistically different. Conclusion WBC, GR% and ESR were higher in intracranial and extracranial arteries occlusive groups, which suggests that these inflammatory reaction may participate the physiopathologic process of the intracranial or extracranial artery occlusion. Besides, we can find some abnormal change in HDL-C, LDL-C, LA and UA level in the occlusive group,and it will take our more studies for the role of this change in the physiopathologic mechanism of the intracranial or extracranial artery occlusion.