CAJ | 학술논문

目的：探讨新辅助化疗预防卵巢恶性肿瘤术后复发的临床效果及化疗后血清肿瘤标志物的变化。方法：将我院收治的82例卵巢癌患者按照分层随机分组法分为观察组和对照组，对照组给予术后化疗，观察组给予术前化疗，观察两组临床疗效和血清肿瘤标志物含量变化，随访2年，观察两组预后情况及生活质量。结果：观察组临床有效率、理想减灭率及血清肿瘤标志物水平等指标均显著优于对照组，两组间差异有统计学意义(P＜0.05)；随访2年，观察组2年生存率、无疾病进展时间及生活质量评价等指标均显著优于对照组，两组间差异有统计学意义(P＜0.05)。结论：新辅助化疗能显著提高临床疗效和延长生存期，对于预防疾病复发和改善患者生活质量均具有积极意义。
목적：탐토신보조화료예방란소악성종류술후복발적림상효과급화료후혈청종류표지물적변화。방법：장아원수치적82례란소암환자안조분층수궤분조법분위관찰조화대조조，대조조급여술후화료，관찰조급여술전화료，관찰량조림상료효화혈청종류표지물함량변화，수방2년，관찰량조예후정황급생활질량。결과：관찰조림상유효솔、이상감멸솔급혈청종류표지물수평등지표균현저우우대조조，량조간차이유통계학의의(P＜0.05)；수방2년，관찰조2년생존솔、무질병진전시간급생활질량평개등지표균현저우우대조조，량조간차이유통계학의의(P＜0.05)。결론：신보조화료능현저제고림상료효화연장생존기，대우예방질병복발화개선환자생활질량균구유적겁의의。
Objective: To explore the clinical effect of neoadjuvant chemotherapy in preventing recurrence of ovarian cancer and the impact of serum tumor markers. Methods: According to a stratified randomization method, 82 cases of ovarian cancer patients were divided into the observation group and the control group in our hospital, the control group was given chemotherapy after surgery, the observation group was given chemotherapy before surgery, two groups of the clinical efficacy and serum levels of tumor markers were observed, fol ow-up 2-years, two groups of prognosis and quality of life were observed. Results: The observation group was significantly bet er than the control group in the clinical efficiency, the ideal rate of tumor cytoreductive and the serum levels of tumor markers, the difference was statistical y significant(P<0.05);fol ow-up 2-years, the observation group was significantly bet er than the control group in the 2-year survival, the disease-free interval and the quality of life, the difference was statistical y significant(P<0.05). Conclusion: Neoadjuvant chemotherapy can significantly improve the clinical efficacy and prolong survival, it has important clinical value in the improving quality of life and prevention of disease recurrence.