中国医科大学学报
中國醫科大學學報
중국의과대학학보
JOURNAL OF CHINA MEDICAL UNIVERSITY
2014年
5期
449-453
,共5页
胃肠道间质瘤%DOG1%CD117%Ki67增殖指数%危险度
胃腸道間質瘤%DOG1%CD117%Ki67增殖指數%危險度
위장도간질류%DOG1%CD117%Ki67증식지수%위험도
gastrointestinal stromal tumors%DOG1%CD117%Ki67%risk rank
目的：探讨DOG1、CD117和Ki67在胃肠道间质瘤中表达及其与临床病理因素的相关性和危险度的关系。方法应用免疫组化方法检测DOG1、CD117和Ki67在66例GIST中表达情况，并对病例进行危险度分级，分析上述免疫组化指标与临床病理相关因素和危险度之间的关系。结果在66例GIST中，DOG1表达阳性率为93.94%，CD117表达阳性率为65.15%，其中CD117阴性的GIST中DOG1阳性表达率为82.61%。DOG1和CD117阳性表达率与性别、年龄、部位、肿瘤大小、核分裂数、危险度之间差异均无统计学意义（P>0.05）。但DOG1表达阳性率高于CD117，差异有统计学意义（P<0.01）。Ki67增殖指数<1%，1%~5%和>5%的例数分别为15例、20例、24例。Ki67增殖指数在GIST中阳性表达率为89.39%，Ki67的阳性表达与性别、年龄、部位之间差异无统计学意义（P>0.05），而与肿瘤大小、核分裂数及危险度之间差异有统计学意义（P<0.01），并且Ki67增殖指数与肿瘤大小、核分裂数及危险度之间均呈正相关（r=0.488、r=0.425、r=0.550）。在CD117阳性的GIST中，Ki67阳性表达率高于DOG1阳性的GIST，两者之间差异无统计学意义（P>0.05）。结论在GIST中，DOG1比CD117有更高的敏感性，Ki67增殖指数的表达可与肿瘤大小、核分裂数一起作为判断危险度及预测预后的重要指标。
目的：探討DOG1、CD117和Ki67在胃腸道間質瘤中錶達及其與臨床病理因素的相關性和危險度的關繫。方法應用免疫組化方法檢測DOG1、CD117和Ki67在66例GIST中錶達情況，併對病例進行危險度分級，分析上述免疫組化指標與臨床病理相關因素和危險度之間的關繫。結果在66例GIST中，DOG1錶達暘性率為93.94%，CD117錶達暘性率為65.15%，其中CD117陰性的GIST中DOG1暘性錶達率為82.61%。DOG1和CD117暘性錶達率與性彆、年齡、部位、腫瘤大小、覈分裂數、危險度之間差異均無統計學意義（P>0.05）。但DOG1錶達暘性率高于CD117，差異有統計學意義（P<0.01）。Ki67增殖指數<1%，1%~5%和>5%的例數分彆為15例、20例、24例。Ki67增殖指數在GIST中暘性錶達率為89.39%，Ki67的暘性錶達與性彆、年齡、部位之間差異無統計學意義（P>0.05），而與腫瘤大小、覈分裂數及危險度之間差異有統計學意義（P<0.01），併且Ki67增殖指數與腫瘤大小、覈分裂數及危險度之間均呈正相關（r=0.488、r=0.425、r=0.550）。在CD117暘性的GIST中，Ki67暘性錶達率高于DOG1暘性的GIST，兩者之間差異無統計學意義（P>0.05）。結論在GIST中，DOG1比CD117有更高的敏感性，Ki67增殖指數的錶達可與腫瘤大小、覈分裂數一起作為判斷危險度及預測預後的重要指標。
목적：탐토DOG1、CD117화Ki67재위장도간질류중표체급기여림상병리인소적상관성화위험도적관계。방법응용면역조화방법검측DOG1、CD117화Ki67재66례GIST중표체정황，병대병례진행위험도분급，분석상술면역조화지표여림상병리상관인소화위험도지간적관계。결과재66례GIST중，DOG1표체양성솔위93.94%，CD117표체양성솔위65.15%，기중CD117음성적GIST중DOG1양성표체솔위82.61%。DOG1화CD117양성표체솔여성별、년령、부위、종류대소、핵분렬수、위험도지간차이균무통계학의의（P>0.05）。단DOG1표체양성솔고우CD117，차이유통계학의의（P<0.01）。Ki67증식지수<1%，1%~5%화>5%적례수분별위15례、20례、24례。Ki67증식지수재GIST중양성표체솔위89.39%，Ki67적양성표체여성별、년령、부위지간차이무통계학의의（P>0.05），이여종류대소、핵분렬수급위험도지간차이유통계학의의（P<0.01），병차Ki67증식지수여종류대소、핵분렬수급위험도지간균정정상관（r=0.488、r=0.425、r=0.550）。재CD117양성적GIST중，Ki67양성표체솔고우DOG1양성적GIST，량자지간차이무통계학의의（P>0.05）。결론재GIST중，DOG1비CD117유경고적민감성，Ki67증식지수적표체가여종류대소、핵분렬수일기작위판단위험도급예측예후적중요지표。
Objective To investigate the expression of DOG1,CD117,and Ki-67 in gastrointestinal stromal tumors and explore their relationship with the clinicopathological factors and risk rank of GISTs. Methods Immunohistochemical method was adopted to detected the expression of DOG1,CD117,and Ki67 in 66 cases of GIST. The risks in all cases were also ranked. The correlation between immunohistochemical indicators and clinicopathological factors and risk ranks of GISTs were analyzed. Results Among the 66 GISTs,the positive rates of DOG1 and CD117 were 93.94%and 65.15%. The positive rate of DOG1 in CD117 negative GISTs was 82.61%. had There were no significant difference among groups in gender,age,position,tumor size,tumor mitotic count in the expression of DOG1 and CD117 and risk rank(P>0.05). However,DOG1 was more sensitive than CD117(P<0.01). The number of cases with Ki67 proliferation indices<1%,1%-5%and>5%were 15,20,and 24,respectively. The positive rate of Ki67 was 89.39%. No significant difference was found in the expression of Ki67 among groups in gender,age,and position(P>0.05). Nevertheless,e Ki67 protein expression was positively correlated with the tumor size,tumor mitotic count and risk rank(P<0.01)(r=0.488, r=0.425,r=0.550). The positive rate of Ki67 was a little bit higher in CD117 positive GISTs than the these DOG1 positive cases,but there was no significant difference(P>0.05). Conclusion DOG1 has higher sensitivity than CD117 in GISTs. Ki67 protein,tumor size,and tumor mitotic count were risk indicators for GISTs and could be predictors for prognosis.
