CAJ | 학술논문

[目的]探讨冠状动脉严重狭窄患者的冠状动脉侧支循环（CCC ）形成与血小板源性内皮细胞生长因子（PD-ECGF）浓度的关系。[方法]入选冠状动脉造影术左前降支、左回旋支和右冠状动脉中至少1支狭窄≥90％的患者55例，按照Rentrop分级方法，对CCC进行分级：0级16例，1级14例，2级15例，3级10例；采用酶联免疫吸附法检测患者 PD-ECGF浓度；应用Gensini积分系统评价患者的冠状动脉粥样硬化病变程度。[结果]0和1级组血清PD-ECGF水平明显低于2和3级组。CCC分级与血清PD-ECGF浓度水平呈正相关（r＝0．86， P＜0．01）。血清PD-ECGF浓度与Gensini积分呈正相关（r＝0．93，P＜0．01）。[结论]冠状动脉严重狭窄患者，随着血清PD-ECGF浓度增加，其侧支循环越发达，因此PD-ECGF可能促进了CCC的生成。
[목적]탐토관상동맥엄중협착환자적관상동맥측지순배（CCC ）형성여혈소판원성내피세포생장인자（PD-ECGF）농도적관계。[방법]입선관상동맥조영술좌전강지、좌회선지화우관상동맥중지소1지협착≥90％적환자55례，안조Rentrop분급방법，대CCC진행분급：0급16례，1급14례，2급15례，3급10례；채용매련면역흡부법검측환자 PD-ECGF농도；응용Gensini적분계통평개환자적관상동맥죽양경화병변정도。[결과]0화1급조혈청PD-ECGF수평명현저우2화3급조。CCC분급여혈청PD-ECGF농도수평정정상관（r＝0．86， P＜0．01）。혈청PD-ECGF농도여Gensini적분정정상관（r＝0．93，P＜0．01）。[결론]관상동맥엄중협착환자，수착혈청PD-ECGF농도증가，기측지순배월발체，인차PD-ECGF가능촉진료CCC적생성。
[Objective]To explore the correlation between coronary collateral circulation (CCC) formation and platelet derived endothelial cell growth factor(PD-ECGF) level .[Methods] A total of 55 patients with at least 1 vessel in left anterior descending branches ,left convolution branches and right coronary arteries by cor-onary angiography were enrolled .According to Rentrop grading method ,CCC was classified into grade 0( n=16) ,grade 1( n=14) and grade 3( n=10) .Enzyme linked immunosorbent assay(ELISA) was used to detect PD-ECGF level .Gensini's score system was used to evaluate the extent of coronary artery atherosclerosis .[Results] Serum levels of PD-ECGF in the groups with grade 0 and grade 1 were lower than those in the groups with grade 2 and grade 3 .CCC grade was positively correlated with serum PD-ECGF level(r=0 .86 ,P<0 .01) .Serum PD-ECGF level was positively correlated with Gensini's score(r=0 .93 ,P<0 .01) .[Conclu-sion]CCC is more developed with the increasing of serum PD-ECGF level in patients with severe coronary ar-tery stenosis .Therefore PD-ECGF may promote the formation of CCC .