医学临床研究
醫學臨床研究
의학림상연구
JOURNAL OF CLINICAL RESEARCH
2013年
11期
2141-2143
,共3页
螺杆菌 ,幽门%胃疾病%NF-κB
螺桿菌 ,幽門%胃疾病%NF-κB
라간균 ,유문%위질병%NF-κB
Helicobacter pylori%Stomach Diseases%NF-kappa B
[目的]探讨三叶因子3（TFF3）和核转录因子-κB NF-κB）在胃癌中表达的意义与幽门螺杆菌（Hp）感染的关系。[方法]胃癌组（GC组）70例，肠上皮化生组（IM 组）30例，浅表性胃炎组（CSG组）30例，应用免疫组化方法测定TFF3和NF-κBp65的表达，同时检测Hp感染。[结果]CSG、IM、GC各组织中 TFF3和NF-κB表达水平呈逐渐增强趋势，GC组中 TFF3和 NF-κBp65表达水平均高于CSG 组（ P ＜0．01或0．05）。IM组中 Hp阳性感染率高于CSG组（ P ＜0．05）。IM组中Hp感染者NF-κBp65、TFF3表达显著高于Hp阴性病例（ P ＜0．05），CSG组、GC组中Hp阳性和阴性病例NF-κBp65、TFF3表达差异无统计学意义（ P ＞0．05）。[结论]NF-κB、TFF3高表达可能是胃癌发生的早期事件，联合检测NF-κBp65、TFF3和 Hp感染对胃癌预防及早期诊断有重要的提示作用。
[目的]探討三葉因子3（TFF3）和覈轉錄因子-κB NF-κB）在胃癌中錶達的意義與幽門螺桿菌（Hp）感染的關繫。[方法]胃癌組（GC組）70例，腸上皮化生組（IM 組）30例，淺錶性胃炎組（CSG組）30例，應用免疫組化方法測定TFF3和NF-κBp65的錶達，同時檢測Hp感染。[結果]CSG、IM、GC各組織中 TFF3和NF-κB錶達水平呈逐漸增彊趨勢，GC組中 TFF3和 NF-κBp65錶達水平均高于CSG 組（ P ＜0．01或0．05）。IM組中 Hp暘性感染率高于CSG組（ P ＜0．05）。IM組中Hp感染者NF-κBp65、TFF3錶達顯著高于Hp陰性病例（ P ＜0．05），CSG組、GC組中Hp暘性和陰性病例NF-κBp65、TFF3錶達差異無統計學意義（ P ＞0．05）。[結論]NF-κB、TFF3高錶達可能是胃癌髮生的早期事件，聯閤檢測NF-κBp65、TFF3和 Hp感染對胃癌預防及早期診斷有重要的提示作用。
[목적]탐토삼협인자3（TFF3）화핵전록인자-κB NF-κB）재위암중표체적의의여유문라간균（Hp）감염적관계。[방법]위암조（GC조）70례，장상피화생조（IM 조）30례，천표성위염조（CSG조）30례，응용면역조화방법측정TFF3화NF-κBp65적표체，동시검측Hp감염。[결과]CSG、IM、GC각조직중 TFF3화NF-κB표체수평정축점증강추세，GC조중 TFF3화 NF-κBp65표체수평균고우CSG 조（ P ＜0．01혹0．05）。IM조중 Hp양성감염솔고우CSG조（ P ＜0．05）。IM조중Hp감염자NF-κBp65、TFF3표체현저고우Hp음성병례（ P ＜0．05），CSG조、GC조중Hp양성화음성병례NF-κBp65、TFF3표체차이무통계학의의（ P ＞0．05）。[결론]NF-κB、TFF3고표체가능시위암발생적조기사건，연합검측NF-κBp65、TFF3화 Hp감염대위암예방급조기진단유중요적제시작용。
[Objective] To explore the significance of the expression of trefoil factor family-3(TFF3) and nuclear factor kappa B(NF-κB) in gastric cancer and its correlation with the Helicobacter pylori (H .pylori) in-fection .[Methods]The expression of TFF3 and NF-κBp65 were detected by immunohistochemistry method in gastric cancer group(group GC ,n=70) ,intestinal metaplasis group(group IM ,n=30) and superficial gastri-tis group(group CSG ,n = 30) .Meanwhile H .pylori infection was detected .[Results] The expression of TFF3 and NF-κB in CSG ,IM and GC tissues had a increasing tendency .The expression of TFF3 and NF-κBp65 in group GC were higher than those in group CSG( P<0 .01 or P<0 .05) .The positive rate of H .py-lori infection in group IM was higher than that in group CSG ( P <0 .05) .The expression of TFF3 and NF-κBp65 in patients with H .pylori infection of group IM were markedly higher than those in patients without H . pylori infection( P <0 .05) .There was no significant difference in the expression of TFF3 and NF-κBp65 be-tween H .pylori positive patients and H .pylori negative patients of group CSG and group GC ( P > 0 .05) .[Conclusion] The expression of TFF3 and NF-κB may be an early event of gastric carcinoma .Combination de-tection of NF-κB ,TFF3 and H .pylori infection is of great significance for the prevention and early diagnosis of gastric carcinoma .
