CAJ | 학술논문

目的：探讨恶性肿瘤患者真菌感染的特征，真菌与肿瘤发生、生长繁殖、最终导致死亡的关连。方法：通过研究抚顺市矿务局总医院住院的51例恶性肿瘤患者静脉血中真菌感染的实验室培养结果和镜检图像、50例痰涂片Gram和亚甲蓝染色菌检及细菌培养相关检测，探索真菌与致癌患病的相关性。结果：51例恶性肿瘤患者静脉血中均有真菌检出，并有两种真菌共存现象。患者发病年龄在3～81岁，血液病患者30例，恶性肿瘤患者21例。在恶性肿瘤的21个病例中有男10例、女11例。21个病例中有胃癌5例、肠癌6例、盆腔肿物4例、肺癌3例、肝癌2例、基底细胞癌1例。50例痰涂片Gram染色镜检中有44例真菌阳性，Gram（+）44例，占88%。50例细菌培养血平板培养基上有42例24小时见较小、白色、较干、高庄状菌落，Gram染色镜检真菌呈阳性Gram（+），42例，占84%。结论：菌检及细菌培养相关检测指标资料显示：恶性肿瘤病例的日趋增多与真菌感染的明显上升和发病率成正相关；真菌感染性疾病日趋呈增加趋势，且不易治疗，形成慢性感染性疾病，甚至恶变为癌症；应密切关注真菌感染与肿瘤的发生、生长，最终导致死亡的关联及因果关系。
목적：탐토악성종류환자진균감염적특정，진균여종류발생、생장번식、최종도치사망적관련。방법：통과연구무순시광무국총의원주원적51례악성종류환자정맥혈중진균감염적실험실배양결과화경검도상、50례담도편Gram화아갑람염색균검급세균배양상관검측，탐색진균여치암환병적상관성。결과：51례악성종류환자정맥혈중균유진균검출，병유량충진균공존현상。환자발병년령재3～81세，혈액병환자30례，악성종류환자21례。재악성종류적21개병례중유남10례、녀11례。21개병례중유위암5례、장암6례、분강종물4례、폐암3례、간암2례、기저세포암1례。50례담도편Gram염색경검중유44례진균양성，Gram（+）44례，점88%。50례세균배양혈평판배양기상유42례24소시견교소、백색、교간、고장상균락，Gram염색경검진균정양성Gram（+），42례，점84%。결론：균검급세균배양상관검측지표자료현시：악성종류병례적일추증다여진균감염적명현상승화발병솔성정상관；진균감염성질병일추정증가추세，차불역치료，형성만성감염성질병，심지악변위암증；응밀절관주진균감염여종류적발생、생장，최종도치사망적관련급인과관계。
Objective:To explore the characteristics of fungal infection in patients with malignant tumors, fungi and tumorigenesis, growth, eventual y leading to the death of the relationship. Method:the review analysis of 51 cases of fungal fungal infection in patients with malignant tumor in venous blood culture results and microscopic image, pathology results, and 51 cases of sputum Gram and methylene blue staining bacteria examination and bacterial culture examination index data. Results:51 cases of malignant tumor in venous blood of fungal infection in patients in the 3 to 81 years, 30 patients with hematological diseases, malignant tumors of 21 cases. In 21 patients with malignant tumors:male 10 cases, female 11 cases. Of which:5 cases of gastric cancer, 6 cases of colorectal cancer, 4 cases of pelvic tumor, 3 cases of lung cancer, 2 cases of liver cancer, 1 cases of basal cel carcinoma, both fungi were venous blood, and two fungal species coexistence. 51 cases of sputum. Gram staining was positive in 44 Gram (+), 88%. 51 cases of bacterial culture of blood culture in 42 cases, 24 hours to see smal , white, dry, high Zhuang colony based on. Gram staining was positive in Gram (+), 84%. Conclusion: bacteria examination and bacterial culture examination index data show: increasing 1, malignant tumors and increased obviously and the incidence of fungal infection is related to. 2, fungal infection of the disease gradual y increased, and not easy to treat, the formation of chronic infectious diseases. 3, we should pay close at ention to fungal infection and tumorigenesis, growth, resulting in correlation and causation of death.