CAJ | 학술논문

目的：观察红藤方对子宫内膜异位症患者血清基质金属蛋白水解酶-9（ MMP-9）、基质金属蛋白酶抑制剂-1（TIMP-1）水平的影响。方法将73例子宫内膜异位症患者随机分为2组。治疗组37例予红藤方治疗，对照组36例予孕三烯酮治疗。2组均治疗3个月。观察2组治疗前后血清MMP-9、TIMP-1及MMP-9/TIMP-1水平改变情况。并设正常组40例进行对照。结果治疗组、对照组血清MMP-9均高于正常组（P＜0．05），血清TIMP-1均低于正常对照组（P＜0．05），MMP-9/TIMP-1水平与正常对照组比较差异有统计学意义（P＜0．05）。治疗组、对照组治疗后血清MMP-9与正常组比较差异均有统计学意义（P＜0．05）；治疗后对照组与正常组血清TIMP-1比较差异有统计学意义（P＜0．05），而治疗组与正常组比较血清TIMP-1比较差异无统计学意义（P＞0．05）。治疗后治疗组、对照组血清MMP-9/TIMP-1与正常组比较差异均有统计学意义（P＜0．05），但治疗后治疗组更接近于正常组，与对照组比较差异有统计学意义（P＜0．05）。治疗组治疗前后MMP-9及MMP-9/TIMP-1比较差异有统计学意义（P＜0．05）。治疗组治疗前后MMP-9/TIMP-1比较差异有统计学意义（P＜0．01）。对照组治疗前后血清MMP-9、TIMP-1、MMP-9/TIMP-1比较差异无统计学意义（P＞0．05）。结论子宫内膜异位症发生与血清MMP-9、TIMP-1水平失调有关，红藤方作用机制与调整血清MMP-9/TIMP-1表达，抑制异位内膜的侵袭性有关。
목적：관찰홍등방대자궁내막이위증환자혈청기질금속단백수해매-9（ MMP-9）、기질금속단백매억제제-1（TIMP-1）수평적영향。방법장73례자궁내막이위증환자수궤분위2조。치료조37례여홍등방치료，대조조36례여잉삼희동치료。2조균치료3개월。관찰2조치료전후혈청MMP-9、TIMP-1급MMP-9/TIMP-1수평개변정황。병설정상조40례진행대조。결과치료조、대조조혈청MMP-9균고우정상조（P＜0．05），혈청TIMP-1균저우정상대조조（P＜0．05），MMP-9/TIMP-1수평여정상대조조비교차이유통계학의의（P＜0．05）。치료조、대조조치료후혈청MMP-9여정상조비교차이균유통계학의의（P＜0．05）；치료후대조조여정상조혈청TIMP-1비교차이유통계학의의（P＜0．05），이치료조여정상조비교혈청TIMP-1비교차이무통계학의의（P＞0．05）。치료후치료조、대조조혈청MMP-9/TIMP-1여정상조비교차이균유통계학의의（P＜0．05），단치료후치료조경접근우정상조，여대조조비교차이유통계학의의（P＜0．05）。치료조치료전후MMP-9급MMP-9/TIMP-1비교차이유통계학의의（P＜0．05）。치료조치료전후MMP-9/TIMP-1비교차이유통계학의의（P＜0．01）。대조조치료전후혈청MMP-9、TIMP-1、MMP-9/TIMP-1비교차이무통계학의의（P＞0．05）。결론자궁내막이위증발생여혈청MMP-9、TIMP-1수평실조유관，홍등방작용궤제여조정혈청MMP-9/TIMP-1표체，억제이위내막적침습성유관。
Objective To study the effect of sargentgloryvine stem prescription on the levels of matrix met-alloproteinases-9(MMP-9) and tissue inhibitor of matrix metalloproteinase (TIMP-1) in serum of patients with endometriosis.Methods 73 patients with endometriosis were randomly divided into Gestrinone group (n=36) and sargentgloryvine stem prescription group (n=37).The changes of levels of MMP -9,TIMP-1 and MMP-9/TIMP-1 in serum of patients were compared before and after treatment .40 healthy persons were as control group .Results The level of MMP-9 in serum of patients with endometriosis was higher than that of control group (P<0.05).The level of TIMP-1 in serum of patients with endometriosis was lower than that of control group (P<0.05).There was significant difference between treatment group and control group on MMP -9/TIMP-1 before and after treatment (P<0.05).There was significant difference between Gestrinone group ,sargentgloryvine stem prescription group and control group on the MMP -9 level after treatment(P<0.05).There was significant difference between Gestrinone group and control group on the TIMP -1 level after treatment(P<0.05).There was no difference between sargentglo-ryvine stem prescription group and control group on the TIMP -1 level after treatment(P>0.05).There was signifi-cant difference between Gestrinone group and sargentgloryvine stem prescription group on MMP -9/TIMP-1 after treatment(P<0.05).There was significant difference between before and after treatment on MMP -9 and MMP-9/TIMP in sargentgloryvine stem prescription group (P<0.05).There was no significant difference be-tween before and after treatment on MMP -9,TIMP-1 and MMP-9/TIMP in Gestrinone group( P >0.05).Con-clusion The genesis of endometriosis is related to serum MMP -9,TIMP-1 levels disorders.The mechanism of ac-tion for sargentgloryvine stem prescription is related to regulating the expression of serum MMP -9/TIMP-1 and in-hibiting invasiveness of endometriosis .