CAJ | 학술논문

目的：探讨慢性阻塞性肺疾病（COPD）患者血清尿酸（UA）水平以及 UA 与肺功能的关系。方法选择85例COPD 急性加重期患者（AECOPD 组），按肺功能分为Ⅰ、Ⅱ、Ⅲ、Ⅳ四级，选定同期于我院体检的健康老年人60例作为对照组，生化分析仪测序血清尿酸水平。结果 AECOPD 组尿酸水平明显高于对照组，两者差异具有统计学意义（P＜0.05），Ⅰ、Ⅱ、Ⅲ、Ⅳ四级组尿酸水平差异具有统计学意义（P ＜0.05），且尿酸水平与肺功能分级有良好的相关性。结论检测血清尿酸有助于判断 COPD 病情严重程度。
목적：탐토만성조새성폐질병（COPD）환자혈청뇨산（UA）수평이급 UA 여폐공능적관계。방법선택85례COPD 급성가중기환자（AECOPD 조），안폐공능분위Ⅰ、Ⅱ、Ⅲ、Ⅳ사급，선정동기우아원체검적건강노년인60례작위대조조，생화분석의측서혈청뇨산수평。결과 AECOPD 조뇨산수평명현고우대조조，량자차이구유통계학의의（P＜0.05），Ⅰ、Ⅱ、Ⅲ、Ⅳ사급조뇨산수평차이구유통계학의의（P ＜0.05），차뇨산수평여폐공능분급유량호적상관성。결론검측혈청뇨산유조우판단 COPD 병정엄중정도。
Objective To explore the change and significance of uric acid in patient with chronic obstructive pulmonary discase(COPD),and its relation with lung function. Methods A total of 85 acute exacerbated COPD(AECOPD) patients were collected from respiratory department of fifth affiliated hospital of Xin Jiang Medical University. All the AECOPD patients according to lung function were divided into Ⅰ、Ⅱ、Ⅲ、Ⅳ groups. Anther 60 healthy old person were enrolled in this study as control groups. The expression of serum uric acid was statistically analyzed among difference groups. Results The serum uric acid level of AECOPD group were significantly higher than control group(P < 0.05).Uric acid level was increased with the classification of lung function, which had significant difference among the different groups((P < 0.05)).The level of uric acid was positively correlated with classification of lung function. Conclusion Measuring serum uric acid level may be helpful for judging the severity of COPD.