重庆医学
重慶醫學
중경의학
CHONGQING MEDICAL JOURNAL
2013年
34期
4139-4140
,共2页
刘世雷%陈玉东%刘相飞
劉世雷%陳玉東%劉相飛
류세뢰%진옥동%류상비
冠心病%血管性血友病因子%血管性血友病因子蛋白裂解酶%血管形成术 ,经腔 ,经皮冠状动脉
冠心病%血管性血友病因子%血管性血友病因子蛋白裂解酶%血管形成術 ,經腔 ,經皮冠狀動脈
관심병%혈관성혈우병인자%혈관성혈우병인자단백렬해매%혈관형성술 ,경강 ,경피관상동맥
coronary disease%von willebrand factor%von willebrand factor protein lyase%angioplasty,transluminal,percutaneous coronary
目的：通过检测经皮冠状动脉介入（PCI）术前、术后冠心病患者血浆中血管性血友病因子（vWF）及其裂解酶（vWF-cp）水平，了解其与冠心病及 PCI 术的关系。方法根据冠脉造影结果将研究对象分对照组（造影正常）及 PCI 组（经造影确诊为冠心病并行 PIC 术），通过酶联免疫吸附法（ELISA）测定血浆 vWF 浓度和及血浆 vWF-cp 活性水平并进行统计分析。结果术前、术后 PCI 组血浆 vWF 水平明显高于对照组，PCI 术后血浆 vWF 水平明显高于 PCI 术前（P＜0．05）。 PCI 组 vWF-cp 活性水平较对照组降低，而 PCI 术后低于 PCI 术前（P＜0．05）。血浆 vWF 水平随冠心病变严重程度而升高，vWF-cp 活性水平随之降低。结论 vWF 及 vWF-cp 水平随冠脉病变严重程度及血栓风险不同呈增高和减低趋势，在急性冠脉综合征的发病过程中可能起重要作用。 PCI 术后 vWF 及 vWF-cp 水平变化，提示介入治疗一定程度上可增加血栓形成风险。
目的：通過檢測經皮冠狀動脈介入（PCI）術前、術後冠心病患者血漿中血管性血友病因子（vWF）及其裂解酶（vWF-cp）水平，瞭解其與冠心病及 PCI 術的關繫。方法根據冠脈造影結果將研究對象分對照組（造影正常）及 PCI 組（經造影確診為冠心病併行 PIC 術），通過酶聯免疫吸附法（ELISA）測定血漿 vWF 濃度和及血漿 vWF-cp 活性水平併進行統計分析。結果術前、術後 PCI 組血漿 vWF 水平明顯高于對照組，PCI 術後血漿 vWF 水平明顯高于 PCI 術前（P＜0．05）。 PCI 組 vWF-cp 活性水平較對照組降低，而 PCI 術後低于 PCI 術前（P＜0．05）。血漿 vWF 水平隨冠心病變嚴重程度而升高，vWF-cp 活性水平隨之降低。結論 vWF 及 vWF-cp 水平隨冠脈病變嚴重程度及血栓風險不同呈增高和減低趨勢，在急性冠脈綜閤徵的髮病過程中可能起重要作用。 PCI 術後 vWF 及 vWF-cp 水平變化，提示介入治療一定程度上可增加血栓形成風險。
목적：통과검측경피관상동맥개입（PCI）술전、술후관심병환자혈장중혈관성혈우병인자（vWF）급기렬해매（vWF-cp）수평，료해기여관심병급 PCI 술적관계。방법근거관맥조영결과장연구대상분대조조（조영정상）급 PCI 조（경조영학진위관심병병행 PIC 술），통과매련면역흡부법（ELISA）측정혈장 vWF 농도화급혈장 vWF-cp 활성수평병진행통계분석。결과술전、술후 PCI 조혈장 vWF 수평명현고우대조조，PCI 술후혈장 vWF 수평명현고우 PCI 술전（P＜0．05）。 PCI 조 vWF-cp 활성수평교대조조강저，이 PCI 술후저우 PCI 술전（P＜0．05）。혈장 vWF 수평수관심병변엄중정도이승고，vWF-cp 활성수평수지강저。결론 vWF 급 vWF-cp 수평수관맥병변엄중정도급혈전풍험불동정증고화감저추세，재급성관맥종합정적발병과정중가능기중요작용。 PCI 술후 vWF 급 vWF-cp 수평변화，제시개입치료일정정도상가증가혈전형성풍험。
Objective Through detecting the levels of von willebrand factor (vWF) ,vWF-cleaving protease (vWF-cp)before and after percataneous coronary intervention (PCI) in patients with coronary atherosclerotic heart disease ,to evaluate the relationship between them .Methods According to the results of coronary angiography ,study objects were divided into control group (normal) and PCI group ( the diagnosis of coronary heart disease with PCI operation ) .Enzyme-linked immunosorbent assay (ELISA) was carrout to determin the levels of plasma vWF concentration and vWF-cp activity in plasma and statistical analysis .Results The pre-operative ,postoperative vWF levels in plasma in PCI group were significantly higher than that in the normal control group ;The plasma vWF levels after PCI were significantly higher than that in the group before PCI (P< 0 .05) ;vWF-cp level of the PCI group were lower than in the control group ,and postoperation is lower than preoperation ( P < 0 .05) .With the coronary artery lesion worsen ,the plasma level of vWF increased ,while the level of vWF-cp activity decreased .Conclusion vWF and vWF-cp levels with the severity of coronary atherosclerosis and thrombosis risk was increased in different decreased ,which may play an important role in the pathogenesis of acute coronary syndromes .Changes of vWF and vWF-cp level after PCI indicate that interventional therapy can increase the risk of thrombosis to some extent .
