CAJ | 학술논문

目的：考察吴茱萸挥发油、芥子油、大黄总蒽醌作为促渗剂对芍药苷经皮渗透的影响。方法采用YB-P6型智能透皮试验仪,以小鼠离体腹部皮肤为渗透屏障,采用高效液相色谱法对芍药苷含量进行测定,考察吴茱萸挥发油、芥子油、大黄总蒽醌3种促渗剂在12 h内对芍药苷累积渗透量、透皮吸收速率、透皮时滞等体外透皮吸收动力学参数的影响。结果吴茱萸挥发油、芥子油、大黄总蒽醌的渗透速率分别为8.1886、3.4117、1.2303 g/(cm2?h),增渗倍数分别为22.6、9.40、3.40,透皮时滞分别为0.93、0.51、0.83 h。结论3种天然透皮促渗剂均能明显促进芍药苷的透皮吸收,为其作为透皮促渗剂提供了参考依据。
목적：고찰오수유휘발유、개자유、대황총은곤작위촉삼제대작약감경피삼투적영향。방법채용YB-P6형지능투피시험의,이소서리체복부피부위삼투병장,채용고효액상색보법대작약감함량진행측정,고찰오수유휘발유、개자유、대황총은곤3충촉삼제재12 h내대작약감루적삼투량、투피흡수속솔、투피시체등체외투피흡수동역학삼수적영향。결과오수유휘발유、개자유、대황총은곤적삼투속솔분별위8.1886、3.4117、1.2303 g/(cm2?h),증삼배수분별위22.6、9.40、3.40,투피시체분별위0.93、0.51、0.83 h。결론3충천연투피촉삼제균능명현촉진작약감적투피흡수,위기작위투피촉삼제제공료삼고의거。
Objective To investigate the effects of volatile oil of Fructus Evodia, mustar d oil and total anthraquinone in Rheum on the transcutaneous permeability of paeoniflorin. Methods Using intelligent transdermal diffusion cell and excised mice skin in vitro as transdermal barrier, the kinetics parameters such as cumulative permeation quantity, permeation rate and permeation lagged time of the three kinds of penetration enhancers on paeoniflorin were determined by HPLC in 12 hours. Results The penetration rate of volatile oil of Fructus Evodia, mustard oil and total anthraquinone in Rheum were 8.188 6, 3.411 7, 1.230 3 μg/(cm2?h), respectively, the enhancement ratios were 22.6, 9.40, 3.40, respectively, and the permeation lagged times were 0.93, 0.51, 0.83 h, respectively. Conclusion Three penetration enhancers all can enhance previously percutaneous absorption of paeoniflorin, which provides reference for the selection of the penetration enhancers of transdermal delivery.