中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
1期
8-9,10
,共3页
李绍军%张翠生%孙世杰%刘小方
李紹軍%張翠生%孫世傑%劉小方
리소군%장취생%손세걸%류소방
急性胰腺炎%早期%IL-6%动态变化
急性胰腺炎%早期%IL-6%動態變化
급성이선염%조기%IL-6%동태변화
Acute pancreatitis%Early%IL-6%Dynamic change
目的：探讨急性胰腺炎早期IL-6变化及与疾病严重程度相关性。方法：选取2008年2月-2013年2月本院住院的101例AP患者，根据病情程度将其分为轻症组43例，中重症组31例，重症组27例，同时选取30例健康查体者作为对照组。应用双抗体夹心免疫发光法测定患者第1、3、7、10天血清中IL-6含量，比较三组患者之间IL-6含量变化。结果：在组间比较中，轻症患者d1、d3及d7血清IL-6含量明显高于对照组，差异均有统计学意义（P<0.05），d10血清IL-6含量虽比对照组高，但差异无统计学意义（P>0.05）；中重症及重症患者d1、d3、d7及d10血清IL-6含量明显高于对照组，中重症患者四次测量IL-6含量水平明显高于轻症患者，重症患者四次测量IL-6含量水平明显高于中重型及轻型，比较差异均有统计学意义（P<0.05）。在组内比较中，轻症组及中重症组患者组内d1、d3、d7及d10血清IL-6含量比较差异均有统计学意义（P<0.05）；重症患者d1与d3、d7与d10差异有统计学意义（P<0.05），而d3及d7差异无统计学意义（P>0.05）。结论：血清IL-6含量动态变化可以作为胰腺炎病情发展的监控指标。
目的：探討急性胰腺炎早期IL-6變化及與疾病嚴重程度相關性。方法：選取2008年2月-2013年2月本院住院的101例AP患者，根據病情程度將其分為輕癥組43例，中重癥組31例，重癥組27例，同時選取30例健康查體者作為對照組。應用雙抗體夾心免疫髮光法測定患者第1、3、7、10天血清中IL-6含量，比較三組患者之間IL-6含量變化。結果：在組間比較中，輕癥患者d1、d3及d7血清IL-6含量明顯高于對照組，差異均有統計學意義（P<0.05），d10血清IL-6含量雖比對照組高，但差異無統計學意義（P>0.05）；中重癥及重癥患者d1、d3、d7及d10血清IL-6含量明顯高于對照組，中重癥患者四次測量IL-6含量水平明顯高于輕癥患者，重癥患者四次測量IL-6含量水平明顯高于中重型及輕型，比較差異均有統計學意義（P<0.05）。在組內比較中，輕癥組及中重癥組患者組內d1、d3、d7及d10血清IL-6含量比較差異均有統計學意義（P<0.05）；重癥患者d1與d3、d7與d10差異有統計學意義（P<0.05），而d3及d7差異無統計學意義（P>0.05）。結論：血清IL-6含量動態變化可以作為胰腺炎病情髮展的鑑控指標。
목적：탐토급성이선염조기IL-6변화급여질병엄중정도상관성。방법：선취2008년2월-2013년2월본원주원적101례AP환자，근거병정정도장기분위경증조43례，중중증조31례，중증조27례，동시선취30례건강사체자작위대조조。응용쌍항체협심면역발광법측정환자제1、3、7、10천혈청중IL-6함량，비교삼조환자지간IL-6함량변화。결과：재조간비교중，경증환자d1、d3급d7혈청IL-6함량명현고우대조조，차이균유통계학의의（P<0.05），d10혈청IL-6함량수비대조조고，단차이무통계학의의（P>0.05）；중중증급중증환자d1、d3、d7급d10혈청IL-6함량명현고우대조조，중중증환자사차측량IL-6함량수평명현고우경증환자，중증환자사차측량IL-6함량수평명현고우중중형급경형，비교차이균유통계학의의（P<0.05）。재조내비교중，경증조급중중증조환자조내d1、d3、d7급d10혈청IL-6함량비교차이균유통계학의의（P<0.05）；중증환자d1여d3、d7여d10차이유통계학의의（P<0.05），이d3급d7차이무통계학의의（P>0.05）。결론：혈청IL-6함량동태변화가이작위이선염병정발전적감공지표。
Objective:To investigate the changes of IL-6 in early stage of acute pancreatitis and its correlation with disease severity.Method:One hundred and one patients with acute pancreatitis in our hospital from February 2008 to February 2013 were selected,according to the severity of disease they were divided into the mild group for 43 cases,the moderate group for 31 cases,the severe group for 27 cases,at the same time 30 healthy people were selected as the control group.IL-6 in serum was detected by double antibody sandwich chemiluminescent immunoassay in the first,third,seventh, tenth day,changes in the content of IL-6 in three groups were compared.Result:In the comparison of groups,the content of serum IL-6 of mild patients in d1,d3 and d7 were significantly higher than those in the control group,the differences were statistically significant(P<0.05),the serum IL-6 content of d10 was higher than that of the control group,but there was no statistically significant difference(P>0.05).The serum IL-6 content of moderate and severe patients in d1,d3,d7 and d10 were significantly higher than that of the control group,in moderate patients with four times of measurement of IL-6 content level was significantly higher than the mild patients,severe patients with four times of measurement of IL-6 content was significantly higher than that of moderate and mild patients,the differences were statistically significant(P<0.05). Within the group comparison,the content of serum IL-6 of the mild and moderate patients in d1,d3,d7 and d10,the differences were statistically significant(P<0.05),the difference of severe patients was statistically significant in d1 and d3,d7 and d10(P<0.05),no significant differences in d3 and d7(P>0.05).Conclusion:Serum IL-6 content changes can be used as a monitoring index of the development of pancreatitis.
