CAJ | 학술논문

目的：通过对排卵障碍患者的观察和治疗资料进行临床分析，探讨排卵障碍性不孕症的临床特点及治疗策略。方法回顾分析2008年4月至2012年4月中630个B超监测自然排卵周期和促排卵周期的临床资料，分析排卵障碍的常见病因、临床表现以及不同促排卵方案的临床结局。结果自然排卵周期中排卵障碍周期约占41．61％，排卵障碍周期中以多囊卵巢综合征（PCOS）患者最为常见。通过促排卵治疗，60．84％的治疗周期有正常排卵，其中克罗米酚50 mg方案及克罗米酚50 mg联合尿促性素方案治疗周期排卵成功率较高，分别为66．49％、67．57％，与其他方案比较，差异有统计学意义（ P＜0．05）。排卵障碍以无排卵为主要表现，其次为小卵泡排卵及卵泡黄素化未破裂。结论排卵障碍是不孕症常见病因，明确其病因及临床特点，制订适宜、高效的促排卵治疗方案可提高其正常排卵率，增加受孕机会。
목적：통과대배란장애환자적관찰화치료자료진행림상분석，탐토배란장애성불잉증적림상특점급치료책략。방법회고분석2008년4월지2012년4월중630개B초감측자연배란주기화촉배란주기적림상자료，분석배란장애적상견병인、림상표현이급불동촉배란방안적림상결국。결과자연배란주기중배란장애주기약점41．61％，배란장애주기중이다낭란소종합정（PCOS）환자최위상견。통과촉배란치료，60．84％적치료주기유정상배란，기중극라미분50 mg방안급극라미분50 mg연합뇨촉성소방안치료주기배란성공솔교고，분별위66．49％、67．57％，여기타방안비교，차이유통계학의의（ P＜0．05）。배란장애이무배란위주요표현，기차위소란포배란급란포황소화미파렬。결론배란장애시불잉증상견병인，명학기병인급림상특점，제정괄의、고효적촉배란치료방안가제고기정상배란솔，증가수잉궤회。
Objective Through observing and treating the ovulation dysfunction patients with birth demand ,to study the clinic characteristics and therapy strategy .Methods 630 clinical cases including natural cycles and controlled ovarian stimulated cycles . monitored by transvaginal B-ultrasonography from April 2008 to April 2012 ,The common reasons ,clinical manifestation ,and out-come undergoing different treatment strategies were analyzed .Results In the natural cycles ,41 .61% patients suffered ovulation dysfunction ,PCOS patients occupied the most .Through the therapy of controlled ovarian stimulating on these patients ,60 .84% of ovulation dysfunction patients recovered normal ovulation .The therapeutic regimen of clomiphene citrate (CC) 50 mg and of CC combined with human menopausal gonadotropin(HMG) showed a higher ovulation rate ,66 .49% and 67 .57% respectively(P<0 .05) .Anovulia was the most commonly type of the ovulation dysfunction ,followed small follicle ovulation and luteinizing unrup-tured follicle .Conclusion Ovulation dysfunction is frequent in infertility patients .Understanding the clinical characteristic and the disease cause ,working out the favourable and effective therapeutic regimen can increase their conception possibility .