CAJ | 학술논문

目的：动态观察氧化低密度脂蛋白（Ox-LDL）、血栓前体蛋白（TpP）在急性脑梗死中的表达，并探讨其临床意义。方法采用酶联免疫吸附试验（ELISA）法测定44例脑梗死患者（脑梗死组）急性期、恢复期及30例健康对照者（对照组）血清Ox-LDL及血浆TpP水平，并对脑梗死患者行美国国立卫生研究院卒中量表（NIHSS）评分，分析Ox-LDL、TpP在急性脑梗死中的表达与NIHSS评分的关系。结果脑梗死患者血清Ox-LDL和血浆TpP均较对照组升高，急性期Ox-LDL及TpP显著高于恢复期及对照组，差异具有统计学意义（P＜0．01）；脑梗死组TpP含量与NIHSS评分呈正相关（P＜0．01），Ox-LDL含量高低与NIH-SS评分无关（P＞0．05）；脑梗死组Ox-LDL与TpP水平呈正相关（r＝0．521，P＜0．05）。结论脑梗死患者血清Ox-LDL、血浆T pP表达上调，且其水平随临床病程不同而发生变化，它们可能协同参与了急性脑梗死的发生、发展；血浆 T pP可能与脑梗死的严重程度相关，或可作为急性脑梗死病情及预后判断的指标。
목적：동태관찰양화저밀도지단백（Ox-LDL）、혈전전체단백（TpP）재급성뇌경사중적표체，병탐토기림상의의。방법채용매련면역흡부시험（ELISA）법측정44례뇌경사환자（뇌경사조）급성기、회복기급30례건강대조자（대조조）혈청Ox-LDL급혈장TpP수평，병대뇌경사환자행미국국립위생연구원졸중량표（NIHSS）평분，분석Ox-LDL、TpP재급성뇌경사중적표체여NIHSS평분적관계。결과뇌경사환자혈청Ox-LDL화혈장TpP균교대조조승고，급성기Ox-LDL급TpP현저고우회복기급대조조，차이구유통계학의의（P＜0．01）；뇌경사조TpP함량여NIHSS평분정정상관（P＜0．01），Ox-LDL함량고저여NIH-SS평분무관（P＞0．05）；뇌경사조Ox-LDL여TpP수평정정상관（r＝0．521，P＜0．05）。결론뇌경사환자혈청Ox-LDL、혈장T pP표체상조，차기수평수림상병정불동이발생변화，타문가능협동삼여료급성뇌경사적발생、발전；혈장 T pP가능여뇌경사적엄중정도상관，혹가작위급성뇌경사병정급예후판단적지표。
Objective Dynamic observation of oxidized low density lipoprotein(Ox-LDL) and thrombus precursor protein(TpP) expressed in patients with acute cerebral infarction ,and explore its clinical significance .Methods To detect the Ox-LDL and the plasma TpP level of 44 patients with acute cerebral infarction (ACI)respectively in acute stage and recovery stage ,and the healthy 30 cases (control group)by using enzyme-linked immunosorbent assay (ELISA) method ,and all the ACI cases were scored by the national institutes of health stroke scale (NIHSS) .To analyze the expression of Ox-LDL and plasma TpP in patients with ACI ,and the relationship with the NIHSS score .Results Ox-LDL and plasma TpP in patients with ACI all increased compared with the con-trol group .Ox-LDL and TpP in acute stage were significantly higher than the corresponding recovery stage and the control group , the difference was statistically significant (P<0 .01) .The levels of plasma TpP were positively correlated with the NIHSS score (P<0 .01) ,and Ox-LDL levels were uncorrelated with the NIHSS score (P>0 .05) .The levels of Ox-LDL were positively correla-ted with TpP in ACI group (r=0 .521 ,P<0 .05) .Conclusion The expression of Ox-LDL and plasma TpP in ACI were increased , Ox-LDL and plasma TpP level in ACI varies with changes of clinical course ,and maybe involved in the coordination and the devel-opment process of ACI ;Plasma TpP may be relevant to the seriousness of cerebral infarction ,and may be arguably used as the measurement of ACI patient′s conditions as well as the prognosis estimation .