CAJ | 학술논문

目的：分析动物模型口腔种植体周围炎龈沟液中IL-6、NF-κB的表达情况。方法：选取5只成年杂种犬，每只犬全麻下拔除下颌前磨牙，即刻植入种植体，植入3个月确定骨结合后，丝线栓结法建立实验性动物口腔种植体周围炎模型， ELISA方法测量出种植体周围炎模型建立前后IL-6、NF-κB的含量并进行分析。结果：种植体周围炎模型建立后骨缺损呈楔形吸收；健康种植体周围龈沟液中检测到极少量IL-6及少量NF-κB；种植体周围炎龈沟液中检测到较多IL-6和NF-κB含量。结论：丝线栓结法可成功建立与临床实际近似的种植体周围炎模型。 IL-6、NF-κB参与实验性动物口腔种植体周围炎发生、发展。
목적：분석동물모형구강충식체주위염간구액중IL-6、NF-κB적표체정황。방법：선취5지성년잡충견，매지견전마하발제하합전마아，즉각식입충식체，식입3개월학정골결합후，사선전결법건립실험성동물구강충식체주위염모형， ELISA방법측량출충식체주위염모형건립전후IL-6、NF-κB적함량병진행분석。결과：충식체주위염모형건립후골결손정설형흡수；건강충식체주위간구액중검측도겁소량IL-6급소량NF-κB；충식체주위염간구액중검측도교다IL-6화NF-κB함량。결론：사선전결법가성공건립여림상실제근사적충식체주위염모형。 IL-6、NF-κB삼여실험성동물구강충식체주위염발생、발전。
Objective:To analyze IL-6, NF-κB expression in oral peri-implantitis GCF of animal models. Methods:Select 5 mon-grel dogs, Each dog Immediate Implant after extraction of mandibular premolars , 3 months after extraction,Silk knot can successfully es-tablished the peri-implantitis, Contents of IL-6、NF-κB were evaluated by enzyme-linked immunosorbent assay before and after per-i-implantitis models were built. Results:Absorption of alveolar bone wedge after periimplantitis animal models were built;Healthy per-i-implant was detected in a very small content of IL-6, and a small content of NF-κB;peri-implantitis detected more IL-6 and NF-κB content. Conclusion:Silk knot can successfully established the peri-implantitis. IL-6, NF-κB involved in peri-implantitis develop-ment.