CAJ | 학술논문

目的：建立尼美舒利有关物质检查的HPLC方法。用十八烷基硅烷键合硅胶为填充剂(4.6mm×150mm，5μ)；流动相：0.1%的磷酸溶液（用氨水调pH7.0）乙腈（6：4），检测波长：230nm，流速：1.0mL·min-1，色谱柱温为室温。本方法专属性强、准确度高、重现性好，可用于尼美舒利质量控制。
목적：건립니미서리유관물질검사적HPLC방법。용십팔완기규완건합규효위전충제(4.6mm×150mm，5μ)；류동상：0.1%적린산용액（용안수조pH7.0）을정（6：4），검측파장：230nm，류속：1.0mL·min-1，색보주온위실온。본방법전속성강、준학도고、중현성호，가용우니미서리질량공제。
Objective:A HPLC method was established for relative substances of nimesulide. A C18(4.6mm×150mm,5μ) was used with acetonitrile and a mixture of acetonitrile -0.1% phosphoric acid adjusted to pH7.0 with ammonia (4:6) as the mobile phase. Detection wavelength is at 230nm. The flow rate was 1.0mL·min-1. The method is simple, accurate, reproducible and can be used for quality of nimesulide.