CAJ | 학술논문

目的：观察反式白藜芦醇（TR）对痴呆大鼠海马旁回的作用。方法：大鼠随机分为给药组和对照组。在大鼠海马内注射Aβ25-35后5天，采用TUNEL法检测5组大鼠海马细胞及周围皮质凋亡情况，采用real time RT-PCR法检测两组大鼠海马及皮质iNOS、caspase-3表达。结果：对大鼠海马以及周边区域的iNOS、caspase-3的表达进行分析结果，给药组的iNOS、caspase-3表达水平下调2.59%，明显低于对照组的9.33%，差异有统计学意义。结论：TR对损伤的大鼠海马周围皮层神经元有保护作用，其机制可能部分与下调iNOS、caspase-3表达有关。
목적：관찰반식백려호순（TR）대치태대서해마방회적작용。방법：대서수궤분위급약조화대조조。재대서해마내주사Aβ25-35후5천，채용TUNEL법검측5조대서해마세포급주위피질조망정황，채용real time RT-PCR법검측량조대서해마급피질iNOS、caspase-3표체。결과：대대서해마이급주변구역적iNOS、caspase-3적표체진행분석결과，급약조적iNOS、caspase-3표체수평하조2.59%，명현저우대조조적9.33%，차이유통계학의의。결론：TR대손상적대서해마주위피층신경원유보호작용，기궤제가능부분여하조iNOS、caspase-3표체유관。
Objective:to observe the trans resveratrol (TR) parahippocampal gyrus of dementia rats. Methods rats were randomly di-vided into to the medicine group and the control group. In rat hippocampal within five days after the injection of A beta 25 to 35, 5 groups of rat hippocampal cells by TUNEL method and the surrounding cortex apoptosis, using real time rt-pcr method to detect two groups of rats hippocampus and cortex iNOS, caspase 3 expression. Results of rat hippocampus and the surrounding area of the expression of iNOS and caspase 3 is analyzed as a result, the drug group of iNOS, caspase 3 expression levels by 2.59%, significantly lower than the control group 9.33%, the difference was statistically significant. Conclusion TR to injury in the rat hippocampus cortex neurons around a protective effect, its mechanism may be partially cut iNOS, caspase 3 expression and expression.