CAJ | 학술논문

目的：探讨力尔凡膀胱灌注预防浅表性膀胱尿路上皮癌术后复发。方法将152例浅表性膀胱尿路上皮癌术后患者随机分成两组。试验组：力尔凡＋DDP＋放疗；对照组：DDP＋放疗。比较两组复发率、复发间隔时间，观察治疗前后T细胞亚群和白细胞总数。结果不同手术方式的复发率、复发间隔时间差异不显著（P＞0．05）；而试验组与对照组复发率、复发间隔时间比较均有显著性差异（ P＜0．05及P＜0．01）；试验组治疗前后NK细胞及CD4/CD8值比较有显著性差异（P＜0．01），治疗后明显高于治疗前，对照组则无显著性差异；试验组治疗前后白细胞总数比较无显著性差异（P＞0．05），对照组则有显著性差异（P＜0．01），治疗后明显低于治疗前。结论力尔凡不但可以杀灭肿瘤细胞，而且有免疫复苏作用，在体内与其他免疫因子和化疗药物起协同作用，对膀胱尿路上皮癌不失为1种化疗配伍的安全、有效的药物。
목적：탐토력이범방광관주예방천표성방광뇨로상피암술후복발。방법장152례천표성방광뇨로상피암술후환자수궤분성량조。시험조：력이범＋DDP＋방료；대조조：DDP＋방료。비교량조복발솔、복발간격시간，관찰치료전후T세포아군화백세포총수。결과불동수술방식적복발솔、복발간격시간차이불현저（P＞0．05）；이시험조여대조조복발솔、복발간격시간비교균유현저성차이（ P＜0．05급P＜0．01）；시험조치료전후NK세포급CD4/CD8치비교유현저성차이（P＜0．01），치료후명현고우치료전，대조조칙무현저성차이；시험조치료전후백세포총수비교무현저성차이（P＞0．05），대조조칙유현저성차이（P＜0．01），치료후명현저우치료전。결론력이범불단가이살멸종류세포，이차유면역복소작용，재체내여기타면역인자화화료약물기협동작용，대방광뇨로상피암불실위1충화료배오적안전、유효적약물。
Objective To evaluate intravesical Lifein instillation in prophylaxis of postoperative recurrence of superficial bladder urothelial carcinoma .Methods 152 cases of superficial bladder urothelial carcinoma patients after operation were ran -domized into the experimental group ( intravesical Lifein instillation +DDP +Radiotherapy ) and the control group ( DDP +Radiotherapy ) .Recurrence rate ,recurrence interval of the 2 groups were compared ,T cell subsets and leukocyte counts before and after treatment were observed .Results Recurrence rates and recurrence interval of different surgical approaches had no signifi -cant differences ( P>0.05) ,but the recurrence rates and recurrence interval between the experimental group and the control group had significant differences (P<0.05,P<0.01 ).NK cell and CD4/CD8 after treatment were significantly higher than be-fore treatment in the experimental group ( P<0.01 ),but there had no significant differences in the control group ( P>0.05). The leukocyte counts in the experimental group before and after treatment had no significant differences ( P>0.05),but there had significant differences in the control group ( P<0.01 ) .Conclusion Intravesical Lifein instillation can kill tumor cells ,and is helpful for immune recovery .There is a synergistic effect among intravesical Lifein instillation ,immune factors and chemothera-py drugs in patients with superficial bladder .urothelial carcinoma .It is a safe and effective compatibility of medicines for chemo-therapy in superficial bladder urothelial carcinoma .