CAJ | 학술논문

目的观察氟比洛芬酯注射液对经尿道前列腺电切术( TUR-P)后膀胱痉挛性疼痛的治疗效果及其不良反应。方法将40名良性前列腺增生并将进行TUR-P术的患者随机分成观察组( n=20)和对照组( n=20)。术后患者出现膀胱痉挛性疼痛时,观察组患者使用100 mg氟比洛芬酯配比500 mL生理盐水静脉滴注,若有需要,可加药静脉续滴；对照组患者肌肉注射盐酸哌替啶100 mg,若效果不理想则肌肉注射盐酸布桂嗪100 mg,于用药后30 min,1 h,2 h,4 h,6 h,8 h对2组患者进行视觉模拟评分( VAS),观察并记录用药后副作用及并发症的发生情况。结果观察组和对照组患者在给药后30 min、1 h、2 h的VAS评分无显著差异(P>0.05)；用药后4 h、6 h、8 h的视觉模拟评分观察组明显低于对照组,在口干、眩晕、恶心、呕吐等不良反应发生率方面观察组也明显低于对照组,具有统计学差异(P<0.05)。2组患者在继发性出血方面则无显著差异(P>0.05)。结论静脉滴注氟比洛芬酯可作为治疗TUR-P术后膀胱痉挛性疼痛的理想方法。
목적관찰불비락분지주사액대경뇨도전렬선전절술( TUR-P)후방광경련성동통적치료효과급기불량반응。방법장40명량성전렬선증생병장진행TUR-P술적환자수궤분성관찰조( n=20)화대조조( n=20)。술후환자출현방광경련성동통시,관찰조환자사용100 mg불비락분지배비500 mL생리염수정맥적주,약유수요,가가약정맥속적；대조조환자기육주사염산고체정100 mg,약효과불이상칙기육주사염산포계진100 mg,우용약후30 min,1 h,2 h,4 h,6 h,8 h대2조환자진행시각모의평분( VAS),관찰병기록용약후부작용급병발증적발생정황。결과관찰조화대조조환자재급약후30 min、1 h、2 h적VAS평분무현저차이(P>0.05)；용약후4 h、6 h、8 h적시각모의평분관찰조명현저우대조조,재구간、현훈、악심、구토등불량반응발생솔방면관찰조야명현저우대조조,구유통계학차이(P<0.05)。2조환자재계발성출혈방면칙무현저차이(P>0.05)。결론정맥적주불비락분지가작위치료TUR-P술후방광경련성동통적이상방법。
Objective To observe the analgesic effect and its complications of flurbiprofen axetil for spastic pain after transurethral re-section of prostate( TUR-P) . Methods 40 patients who were clinically diagnosed as benign prostatic hyperplasia and underwent TUR-P were randomly divided into the experimental group (n=20)and the control group(n=20). When the postsurgical spastic bladder pain happened, the patients in the experimental group received intravenous drip of flurbiprofen axetil 100 mg with saline 500 mL,and the patients in the con-trol group received intramuscular injection of pethidine hydrochloride 100 mg. If its effect is not good,100 mg bucinnazine hydrochloride were injected. Analgesia efficacy was assessed by visual analog scales( VAS) at 30 min,1 h,2 h,4 h,6 h and 8 h after medication. At the same time,the side-effects and complications were observed and recorded. Results There is no statistical difference between the experimental group and the control group at 30 min,1 h, and 2 h after medication(P>0. 05),but at 4 h,6 h and 8 h after medication,VAS score of the experimental group is obviously lower than that of the control group(P<0. 05). And the incidence of adverse reaction of the experimental group, such as thirst,dizziness,nausea and emesia,was lower than that of the control group(P<0. 05). But there is no significant difference in incidence of the secondary bleeding between the two groups(P>0. 05). Conclusion Intravenous drip of flurbiprofen axetil can be an ef-fective and safe way of curing postsurgical spastic bladder pain after TUR-P.