CAJ | 학술논문

目的探讨介入热化疗栓塞( IHC)治疗巨块型原发性肝癌的疗效,并与经肝动脉化疗栓塞( TACE)进行对比。方法 IHC治疗的中晚期巨块型原发性肝癌患者68例作为观察组,同期单纯行TACE治疗32例患者作为对照组。比较2组患者的疗效、生存质量、二次手术率、血清AFP下降程度、生存率及毒副作用。结果观察组有效率(79.4%)显著高于对照组(56.3%), P<0.05。观察组经治疗后二次手术切除率(70.6%)显著高于对照组(43.8%),P<0.01。观察组经治疗后Karnofsky评分增加20分以上者(35.3%)显著高于对照组(12.5%),P<0.01；AFP下降程度大于50%者所占比例(52.9%)显著高于对照组(25.0%), P<0.01。观察组术后12、18、24个月患者存活率均分别显著高于对照组(P<0.01)。结论 IHC治疗巨块型原发性肝癌疗效显著,可增加患者二次手术的机会,是治疗巨块型肝癌安全有效的治疗方式之一。
목적탐토개입열화료전새( IHC)치료거괴형원발성간암적료효,병여경간동맥화료전새( TACE)진행대비。방법 IHC치료적중만기거괴형원발성간암환자68례작위관찰조,동기단순행TACE치료32례환자작위대조조。비교2조환자적료효、생존질량、이차수술솔、혈청AFP하강정도、생존솔급독부작용。결과관찰조유효솔(79.4%)현저고우대조조(56.3%), P<0.05。관찰조경치료후이차수술절제솔(70.6%)현저고우대조조(43.8%),P<0.01。관찰조경치료후Karnofsky평분증가20분이상자(35.3%)현저고우대조조(12.5%),P<0.01；AFP하강정도대우50%자소점비례(52.9%)현저고우대조조(25.0%), P<0.01。관찰조술후12、18、24개월환자존활솔균분별현저고우대조조(P<0.01)。결론 IHC치료거괴형원발성간암료효현저,가증가환자이차수술적궤회,시치료거괴형간암안전유효적치료방식지일。
Objective To explore the effects of the therapeutic effects of interventional heated chemotherapy( IHC) for moderate and advanced huge primary hepatocellular carcinoma and compare with transcatheter arterial chemoembolization( TACE) . Methods The 68 pa-tients with moderate and advanced huge primary hepatocellular carcinoma accepted the treatment of IHC were considered as the observation group,and 32 patients managed TACE were regarded as the control group. The therapeutic effects,living quality,secondary surgery rates,The reduced level of serum AFP,survival rate,and toxic side effects of 2 groups were contrasted. Results The effective rate of observation group was obviously higher than that of control group (79. 4% vs 56. 3%,P <0. 05),and secondary surgery rates was increased(70. 6% vs 43. 8%,P<0. 01). The ratio of increased Karnofsky score was more than 20 in observation group,which was obviously higher than that of control group(35. 3% vs 12. 5%,P<0. 01). T The reduced level of serum AFP was more than 50% in observation group,which was higher than that of control group (52. 9% vs 25. 0%,P<0. 01). The survival rate of 12,18,24 months after treatment in control group was in-creased than that in control group individually (P<0. 01). Conclusion IHC is effective for huge primary hepatocellular carcinoma and in-creases the secondary surgery rates,which is one of the safe and effective methods for huge primary hepatocellular carcinoma.