CAJ | 학술논문

目的研究金丝桃苷( Hyp)对四氯化碳( CCl4)诱导大鼠急性肝损伤的治疗作用。方法采用大鼠CCl4急性肝损伤模型,观察Hyp对急性肝损伤大鼠肝脏组织病理学改变的影响；检测肝组织匀浆中超氧化物歧化酶( T-SOD)、谷胱甘肽( GSH)的活性及丙二醛( MDA)含量变化。结果 CCl4模型组大鼠肝组织HE染色病理检测结果见明显炎症变性坏死及纤维组织增生现象；Hyp高剂量60 mg/kg、中剂量30 mg/kg治疗组的肝组织病理改变明显改善；Hyp治疗组肝组织中T-SOD、GSH活性明显升高,MDA含量明显降低,并存在量效关系。结论 Hyp对CCl4引起的大鼠急性肝损伤有较好的治疗作用,其机制可能与其抗氧化活性有关。
목적연구금사도감( Hyp)대사록화탄( CCl4)유도대서급성간손상적치료작용。방법채용대서CCl4급성간손상모형,관찰Hyp대급성간손상대서간장조직병이학개변적영향；검측간조직균장중초양화물기화매( T-SOD)、곡광감태( GSH)적활성급병이철( MDA)함량변화。결과 CCl4모형조대서간조직HE염색병리검측결과견명현염증변성배사급섬유조직증생현상；Hyp고제량60 mg/kg、중제량30 mg/kg치료조적간조직병리개변명현개선；Hyp치료조간조직중T-SOD、GSH활성명현승고,MDA함량명현강저,병존재량효관계。결론 Hyp대CCl4인기적대서급성간손상유교호적치료작용,기궤제가능여기항양화활성유관。
Objective To study the protective effect of hyperin( Hyp) on the acute liver injury in rats induced by CCl4 . Methods The acute liver injury model was induced by CCl4 . The effect of Hyp on acute liver injury of rat liver histopathology was observed;and the impact of changes of homogenates total superoxide dismutase ( T-SOD) ,glutathione ( GSH) activity and malondialdehyde ( MDA) in liver were de-tected. Results The acute liver injury of tissue induced by CCl4,apparent pathological inflammation and fibrous tissue degeneration and necrosis were observed by HE staining;At the high doses of 60 mg/kg and medium doses of 30 mg/kg treated by Hyp,liver pathology changes was significantly obvious. The T-SOD,GSH activity of liver tissue was significantly increased in the groups of Hyp treatment,MDA content was significantly decreased,which related to the dosages. Conclusion In the rat model of acute liver injury induced by CCl4 . A better therapeu-tic effect of Hyp was shown,the mechanism may be related to its antioxidant activity.