CAJ | 학술논문

目的：观察强心饮对阿霉素诱导的心肌肥厚大鼠相关调控细胞生长与增殖蛋白表达的变化，以探讨强心饮对心肌肥厚潜在的作用机制。方法40只SD大鼠随机分为5组：模型组、正常组、雷帕霉素组、强心饮大剂量组、强心饮小剂量组。采取腹腔注射阿霉素复制大鼠心肌肥厚模型，观察大鼠心肌形态学、血流动力学、心衰指标及调控心肌肥厚相关蛋白表达的变化。结果与模型组比较，强心饮治疗组明显改善心肌肥厚大鼠心脏结构及功能，降低心肌组织BNP含量，抑制调控细胞生长蛋白mTOR及p70S6K的磷酸化（P＜0.01或P＜0.05）。结论强心饮能改善心肌肥厚大鼠心功能及抑制心肌肥厚，其机制可能调控p-mTOR及p-p70S6K的表达有关。
목적：관찰강심음대아매소유도적심기비후대서상관조공세포생장여증식단백표체적변화，이탐토강심음대심기비후잠재적작용궤제。방법40지SD대서수궤분위5조：모형조、정상조、뢰파매소조、강심음대제량조、강심음소제량조。채취복강주사아매소복제대서심기비후모형，관찰대서심기형태학、혈류동역학、심쇠지표급조공심기비후상관단백표체적변화。결과여모형조비교，강심음치료조명현개선심기비후대서심장결구급공능，강저심기조직BNP함량，억제조공세포생장단백mTOR급p70S6K적린산화（P＜0.01혹P＜0.05）。결론강심음능개선심기비후대서심공능급억제심기비후，기궤제가능조공p-mTOR급p-p70S6K적표체유관。
Objective To observe the effects of Qiangxin decoction on protein expression of regulation cell growth and proliferation in Rats with Adriamycin (ADR)-induced cardiac hypertrophy,and to investigate potential molecular mechanisms of cardiac hypertrophy. Methods Forty Sprague Dawley rats were randomly divided as follows:ADR group,normal control group, rapamycin treatment group,high and low dosage Qiangxin decoction groups. The morphology,hemodynamic,brain natriuretic peptide, and relative protein expression of cardiac hypertrophy were observed. Results Compared with ADR group, Qiangxin decoction treatment significantly inhibited the extent of the cardiac hypertrophy,improved cardiac function,while the expression level of phosphorylated mTOR (p-mTOR)and phosphorylated p70S6K (p- p70S6K)significantly reduced. Conclusion The present study demonstrated that Qiangxin decoction significantly relieve the myocardial hypertrophy and improve the cardiac function,The protective effect of the derivatives could be due to the inhibition of the activities of p-mTOR and p-p70S6K.