CAJ | 학술논문

目的：探讨非小细胞肺癌组织中乙酰辅酶A羧化酶磷酸化后的产物（P-ACC）与环氧合酶-2（COX-2）的表达及其与肿瘤大小、淋巴结转移、临床分期及病理类型的关系，并研究两者的相关性。方法：以62例非小细胞肺癌患者的肺癌组织作为研究组，20例因其他它原因行肺叶切除患者的正常肺组织作为对照组。应用免疫组织化学SP法检测肺癌组织及正常肺组织中P-ACC、COX-2的表达情况。结果：P-ACC、COX-2在非小细胞肺癌和正常肺组织中的阳性表达差异有统计学意义（P<0.05）。在非小细胞肺癌中，P-ACC的阳性表达与肿瘤大小显著相关（P<0.05），而与淋巴结转移、临床分期及病理类型无关；COX-2的阳性表达与肿瘤大小、淋巴结转移、临床分期及病理类型无关。P-ACC与COX-2的阳性表达之间呈显著负相关（r=-2.37，P=0.032）。结论：P-ACC在非小细胞肺癌组织中的阳性表达降低；COX-2在非小细胞肺癌组织中阳性高表达，二者呈显著负相关，提示P-ACC阳性表达降低可能激活COX-2阳性表达，可促进非小细胞肺癌的发生、发展及侵袭转移。
목적：탐토비소세포폐암조직중을선보매A최화매린산화후적산물（P-ACC）여배양합매-2（COX-2）적표체급기여종류대소、림파결전이、림상분기급병리류형적관계，병연구량자적상관성。방법：이62례비소세포폐암환자적폐암조직작위연구조，20례인기타타원인행폐협절제환자적정상폐조직작위대조조。응용면역조직화학SP법검측폐암조직급정상폐조직중P-ACC、COX-2적표체정황。결과：P-ACC、COX-2재비소세포폐암화정상폐조직중적양성표체차이유통계학의의（P<0.05）。재비소세포폐암중，P-ACC적양성표체여종류대소현저상관（P<0.05），이여림파결전이、림상분기급병리류형무관；COX-2적양성표체여종류대소、림파결전이、림상분기급병리류형무관。P-ACC여COX-2적양성표체지간정현저부상관（r=-2.37，P=0.032）。결론：P-ACC재비소세포폐암조직중적양성표체강저；COX-2재비소세포폐암조직중양성고표체，이자정현저부상관，제시P-ACC양성표체강저가능격활COX-2양성표체，가촉진비소세포폐암적발생、발전급침습전이。
Objective:A study was conducted to determine the expression of acetyl-coa carboxylase product of phosphorylation (P-ACC) and an enzyme called cyclooxygenase 2 (COX-2) in non-small cell lung cancer (NSCLC) tissue, as well as the relationship and correlations between tumor size, lymph node metastasis, clinical stage, and pathological type. Methods: Sixty-two patients with NSCLC lung cancer tissues were included in the patient group, whereas 20 patients who underwent lobectomy for other reasons and had normal lung tissues were included in the control group. Immunohistochemical streptavidin peroxidase method was used to detect the expression of P-ACC and COX-2 in lung cancer and normal lung tissues. Results:The positive expressions of P-ACC and COX-2 in NSCLC lung cancer and normal lung tissues were significantly different (P<0.05). In NSCLC tissues, the positive expression of P-ACC was significantly associated with tumor size (P<0.05), but was not significantly associated with lymph node metastasis, clinical stage, and pathological type. We found no correlation between the positive expression of COX-2 and tumor size, lymph node metasta-sis, clinical stage and pathological type. Further analysis revealed that the positive expression of P-ACC and COX-2 in NSCLC was sig-nificantly and negatively correlated (r=-2.37, P=0.032). Conclusion:The positive expression of COX-2 in NSCLC greatly increased compared with that of P-ACC, and a significantly negative correlation was observed between them. We propose that the positive expres-sion of P-ACC reduction may activate the positive expression of COX-2 and promote the occurrence, development, invasion, and metas-tasis of NSCLC.