中国肿瘤临床
中國腫瘤臨床
중국종류림상
CHINESE JOURNAL OF CLINICAL ONCOLOGY
2014年
1期
56-59
,共4页
黄小林(综述)%许恒毅(审校)
黃小林(綜述)%許恆毅(審校)
황소림(종술)%허항의(심교)
磁性氧化铁纳米粒子%表面修饰%循环肿瘤细胞%分离
磁性氧化鐵納米粒子%錶麵脩飾%循環腫瘤細胞%分離
자성양화철납미입자%표면수식%순배종류세포%분리
magnetic iron oxide nanoparticles%surface modification%circulating tumor cells%separation
磁性氧化铁纳米粒子(magnetic iron oxide nanoparticles,MIONs)已被广泛应用于靶向药物转运、磁共振成像(MRI)、癌细胞分离和富集及肿瘤靶向治疗等生物医学领域。随着MIONs在生物医学领域应用的不断深入,对MIONs在更低的毒性、更稳定的胶体分散性、更好的生物相容性及更高的磁响应性等方面的性能也提出了更具体的要求。因此,除了材料合成本身需不断改进外,选择合适的修饰材料对MIONs进行表面改性和修饰是至关重要的。本文对MIONs表面修饰的方法和表面修饰的材料及其作用进行了综述,并着重阐述了MIONs在循环肿瘤细胞(circulating tumor cells,CTCs)分离中应用的研究进展。
磁性氧化鐵納米粒子(magnetic iron oxide nanoparticles,MIONs)已被廣汎應用于靶嚮藥物轉運、磁共振成像(MRI)、癌細胞分離和富集及腫瘤靶嚮治療等生物醫學領域。隨著MIONs在生物醫學領域應用的不斷深入,對MIONs在更低的毒性、更穩定的膠體分散性、更好的生物相容性及更高的磁響應性等方麵的性能也提齣瞭更具體的要求。因此,除瞭材料閤成本身需不斷改進外,選擇閤適的脩飾材料對MIONs進行錶麵改性和脩飾是至關重要的。本文對MIONs錶麵脩飾的方法和錶麵脩飾的材料及其作用進行瞭綜述,併著重闡述瞭MIONs在循環腫瘤細胞(circulating tumor cells,CTCs)分離中應用的研究進展。
자성양화철납미입자(magnetic iron oxide nanoparticles,MIONs)이피엄범응용우파향약물전운、자공진성상(MRI)、암세포분리화부집급종류파향치료등생물의학영역。수착MIONs재생물의학영역응용적불단심입,대MIONs재경저적독성、경은정적효체분산성、경호적생물상용성급경고적자향응성등방면적성능야제출료경구체적요구。인차,제료재료합성본신수불단개진외,선택합괄적수식재료대MIONs진행표면개성화수식시지관중요적。본문대MIONs표면수식적방법화표면수식적재료급기작용진행료종술,병착중천술료MIONs재순배종류세포(circulating tumor cells,CTCs)분리중응용적연구진전。
Magnetic iron oxide nanoparticles (MIONs) have been widely used in biomedical fields, including targeted drug deliv-ery, magnetic resonance imaging, separation and enrichment of cancer cells, and tumor-targeted therapy. However, MIONs are increas-ingly necessary to ensure reduced toxicity, more stable colloidal dispersion, better biocompatibility, and higher magnetic responsive-ness. Thus, apart from the continuous improvement of material synthesis, specific surface modification of MIONs is essential to choose appropriate materials. This paper reviews the available methods and materials and their function in MION surface modification as well as their applications for the separation of circulating tumor cells.