CAJ | 학술논문

肿瘤筛查中通常采用多种肿瘤标志物的联合检测以提高诊断率。因此，为了提高筛查效率，亟需一种多元分析技术应用于肿瘤筛查。液相芯片技术是由基因微阵列生物芯片技术演变而来的多元分析技术。它由编码微球、探针分子、目标分子和报告分子四部分组成，可用于目标物的定量分析。微球编码技术是液相芯片技术的研究热点，本文中涉及的光子晶体编码是光学编码策略的一种，具有良好的稳定性和解码性能。长期研究表明，光子晶体编码液相芯片在肿瘤筛查、诊断中应用前景广阔。本文综述了光子晶体编码液相芯片技术的基本原理、技术特点及在肿瘤筛查中的应用现状。
종류사사중통상채용다충종류표지물적연합검측이제고진단솔。인차，위료제고사사효솔，극수일충다원분석기술응용우종류사사。액상심편기술시유기인미진렬생물심편기술연변이래적다원분석기술。타유편마미구、탐침분자、목표분자화보고분자사부분조성，가용우목표물적정량분석。미구편마기술시액상심편기술적연구열점，본문중섭급적광자정체편마시광학편마책략적일충，구유량호적은정성화해마성능。장기연구표명，광자정체편마액상심편재종류사사、진단중응용전경엄활。본문종술료광자정체편마액상심편기술적기본원리、기술특점급재종류사사중적응용현상。
Multiple tumor makers are needed to improve the diagnostic rate of the simultaneously detection of malignant tumors through screening. Therefore, multiplex detection technology is urgently required to improve the screening efficiency. Suspension arrays are multiplex detection method based on gene microarrays. It consists of encoded microbeads, probes, targets, and report molecules are applied to analyze targets quantitatively. The microbead encoding strategy is a hotspot in suspension array research. The photonic crystal encoding mentioned in this review is a type of optical encoding that is very stable and easily decoded. Photonic suspension arrays have broad prospects in the screening and diagnosis of malignant tumors through long-term studies. This review summarizes the basic principle, classification, and characteristics of photonic suspension arrays and their application in the screening of malignant tumors.