CAJ | 학술논문

恶性肿瘤最基本的生物学特征之一是细胞周期调控紊乱导致的细胞恶性转化和肿瘤细胞失控性增殖。了解细胞周期的调控机制能够揭示肿瘤发生发展的本质，阐释癌症的发生机制，从而为肿瘤的早期诊断和临床治疗提供分子标志物及药物靶点。本综述通过分析参与细胞周期运转的重要蛋白分子以及这些分子在细胞癌变和临床肿瘤防治过程中的作用，探讨基于这些分子的药物研发，从而系统地阐述细胞周期紊乱对肿瘤发生发展的生物学影响及其对肿瘤诊断与治疗的理论和实践意义。
악성종류최기본적생물학특정지일시세포주기조공문란도치적세포악성전화화종류세포실공성증식。료해세포주기적조공궤제능구게시종류발생발전적본질，천석암증적발생궤제，종이위종류적조기진단화림상치료제공분자표지물급약물파점。본종술통과분석삼여세포주기운전적중요단백분자이급저사분자재세포암변화림상종류방치과정중적작용，탐토기우저사분자적약물연발，종이계통지천술세포주기문란대종류발생발전적생물학영향급기대종류진단여치료적이론화실천의의。
Dysregulated cell cycle-mediated cell transformation and uncontrolled cell growth are some of the fundamental biolog-ical features of malignant tumors. Thus, understanding the mechanism(s) involved in the cell cycle will facilitate the discovery of the na-ture of tumor initiation and progression as well as the molecular mechanism of tumor malignancy. Consequently, biomarkers and drug targets for early diagnosis and treatment would be obtained. This study was designed to analyze in detail the key regulators of cell cycle and their importance in carcinogenesis and clinical prevention, diagnosis and treatment, and anti-cancer drug discovery. The biological impact of the dysregulated cell cycle on tumor occurrence and malignancy development is systematically described. The theoretical and practical significance of the cell cycle regulation in tumor diagnosis and therapy are also provided.