中国医科大学学报
中國醫科大學學報
중국의과대학학보
JOURNAL OF CHINA MEDICAL UNIVERSITY
2014年
5期
437-440
,共4页
微创%干细胞动员%神经功能修复
微創%榦細胞動員%神經功能脩複
미창%간세포동원%신경공능수복
minimal invasive%stem cell mobilization%neurological functional recovery
目的：观察微创术后骨髓间充质干细胞（BMSCs）动员对脑出血术后神经功能的影响。方法将脑出血患者45例随机分为对照组（n=20，行常规立体定向手术治疗）和治疗组（n=25，术后3~5 d时行BMSCs动员）。术前及术后1、3、6个月行NIHSS量表、FIM量表评分，术前、术后2周测定外周血CD133+、CD34+细胞数，术后1个月及6个月行肝肾功能检查。结果2组术后NIHSS、FIM分值均显著高于术前（P<0.05），治疗组术后NIHSS、FIM分值均显著高于对照组（P<0.05）。术后2周，治疗组外周血CD133+、CD34+细胞在单核细胞中的比例明显高于对照组（P<0.05）。术后1个月及6个月2组肝肾功能检查指标均正常。结论脑出血微创术后尽早进行BMSCs动员，可促进神经功能恢复，提高患者的生活能力和质量。
目的：觀察微創術後骨髓間充質榦細胞（BMSCs）動員對腦齣血術後神經功能的影響。方法將腦齣血患者45例隨機分為對照組（n=20，行常規立體定嚮手術治療）和治療組（n=25，術後3~5 d時行BMSCs動員）。術前及術後1、3、6箇月行NIHSS量錶、FIM量錶評分，術前、術後2週測定外週血CD133+、CD34+細胞數，術後1箇月及6箇月行肝腎功能檢查。結果2組術後NIHSS、FIM分值均顯著高于術前（P<0.05），治療組術後NIHSS、FIM分值均顯著高于對照組（P<0.05）。術後2週，治療組外週血CD133+、CD34+細胞在單覈細胞中的比例明顯高于對照組（P<0.05）。術後1箇月及6箇月2組肝腎功能檢查指標均正常。結論腦齣血微創術後儘早進行BMSCs動員，可促進神經功能恢複，提高患者的生活能力和質量。
목적：관찰미창술후골수간충질간세포（BMSCs）동원대뇌출혈술후신경공능적영향。방법장뇌출혈환자45례수궤분위대조조（n=20，행상규입체정향수술치료）화치료조（n=25，술후3~5 d시행BMSCs동원）。술전급술후1、3、6개월행NIHSS량표、FIM량표평분，술전、술후2주측정외주혈CD133+、CD34+세포수，술후1개월급6개월행간신공능검사。결과2조술후NIHSS、FIM분치균현저고우술전（P<0.05），치료조술후NIHSS、FIM분치균현저고우대조조（P<0.05）。술후2주，치료조외주혈CD133+、CD34+세포재단핵세포중적비례명현고우대조조（P<0.05）。술후1개월급6개월2조간신공능검사지표균정상。결론뇌출혈미창술후진조진행BMSCs동원，가촉진신경공능회복，제고환자적생활능력화질량。
Objective To observe the effects of autologous bone marrow mesenchymal stem cell mobilization on neurological function recovery after cerebral hemorrhage minimally invasive surgery. Methods Totally 45 patients with cerebral hemorrhage were randomly divided into two groups:in-cluding 20 cases in control group whom received stereotactic surgery,and BMSCs mobilization was carried out 3 to 5 days postoperation in the treated group(25 cases). NIHSS scale and FIM scale were performed before the operation and 1,3,6 months post operation. Preoperative and 2 weeks post-operative CD133+CD34+cell count was measured in peripheral blood;postoperative liver and renal function of 1,6 months were performed. Results Postoperative NIHSS,FIM scores were significantly higher than preoperative ones in two groups(P<0.05),postoperative NIHSS scores and FIM scores in treated group were significantly higher than that of control group(P<0.05). Two weeks postoperation,the proportion of CD133+CD34+cells in mononuclear cells in peripheral blood of treated group was significantly higher than the control group(P<0.05). Postoperative liver and renal function of 1,6 months were normal. Conclusion BMSCs mobilization can be performed as early as possible after minimally invasive surgery of ce-rebral hemorrhage,which can promote the recovery of neurological function,improve the capacity and quality of life without adverse reactions.
