国际眼科杂志
國際眼科雜誌
국제안과잡지
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
2014年
1期
109-111
,共3页
原喆%柳力敏%刘磊%华瑞%陈蕾
原喆%柳力敏%劉磊%華瑞%陳蕾
원철%류력민%류뢰%화서%진뢰
非增生性糖尿病视网膜病变%黄斑水肿%黄斑中心凹%多焦视网膜电图%Spectralis相干断层扫描
非增生性糖尿病視網膜病變%黃斑水腫%黃斑中心凹%多焦視網膜電圖%Spectralis相榦斷層掃描
비증생성당뇨병시망막병변%황반수종%황반중심요%다초시망막전도%Spectralis상간단층소묘
nonproliferative diabetic retinopathy%macular edema%fovea%electroretinography%Spectralis OCT
目的：分析非增生性糖尿病视网膜病变（ nonproliferative diabetic retinopathy ，NPDR）无黄斑水肿的患者黄斑中心凹区视网膜功能及厚度间的关系。<br> 方法：选取NPDR患者20例35眼患眼为糖尿病视网膜病变（ diabetic retinopathy ， DR ）组，行多焦视网膜电图（multifocal electronic retinography ， mfERG）及Spectralis 相干断层扫描（ Spectralis optical coherence tomography ， Spectralis OCT ）检查。以15例20眼正常眼为OCT对照组，以19例20眼正常眼为mfERG对照组，OCT对照组做Spectralis OCT检查，mfERG对照组做mfERG检查。<br> 结果：与对照组相比， DR组黄斑中心凹mfERG1环的P1波反应密度减小， P1波及N1波隐含期改变无统计学意义；DR组无水肿的黄斑中心凹视网膜厚度、神经上皮层厚度仍有显著增加。<br> 结论：应用mfERG可以在视网膜无可见明显结构改变之前发现视网膜功能上的异常变化；Spectralis OCT 可以测量视网膜各层厚度，反映视网膜精细结构变化，验证视网膜功能上的异常改变，二者联合应用为极早期发现糖尿病视网膜病变视功能改变提供有效的证据，并为及时治疗提供资料。
目的：分析非增生性糖尿病視網膜病變（ nonproliferative diabetic retinopathy ，NPDR）無黃斑水腫的患者黃斑中心凹區視網膜功能及厚度間的關繫。<br> 方法：選取NPDR患者20例35眼患眼為糖尿病視網膜病變（ diabetic retinopathy ， DR ）組，行多焦視網膜電圖（multifocal electronic retinography ， mfERG）及Spectralis 相榦斷層掃描（ Spectralis optical coherence tomography ， Spectralis OCT ）檢查。以15例20眼正常眼為OCT對照組，以19例20眼正常眼為mfERG對照組，OCT對照組做Spectralis OCT檢查，mfERG對照組做mfERG檢查。<br> 結果：與對照組相比， DR組黃斑中心凹mfERG1環的P1波反應密度減小， P1波及N1波隱含期改變無統計學意義；DR組無水腫的黃斑中心凹視網膜厚度、神經上皮層厚度仍有顯著增加。<br> 結論：應用mfERG可以在視網膜無可見明顯結構改變之前髮現視網膜功能上的異常變化；Spectralis OCT 可以測量視網膜各層厚度，反映視網膜精細結構變化，驗證視網膜功能上的異常改變，二者聯閤應用為極早期髮現糖尿病視網膜病變視功能改變提供有效的證據，併為及時治療提供資料。
목적：분석비증생성당뇨병시망막병변（ nonproliferative diabetic retinopathy ，NPDR）무황반수종적환자황반중심요구시망막공능급후도간적관계。<br> 방법：선취NPDR환자20례35안환안위당뇨병시망막병변（ diabetic retinopathy ， DR ）조，행다초시망막전도（multifocal electronic retinography ， mfERG）급Spectralis 상간단층소묘（ Spectralis optical coherence tomography ， Spectralis OCT ）검사。이15례20안정상안위OCT대조조，이19례20안정상안위mfERG대조조，OCT대조조주Spectralis OCT검사，mfERG대조조주mfERG검사。<br> 결과：여대조조상비， DR조황반중심요mfERG1배적P1파반응밀도감소， P1파급N1파은함기개변무통계학의의；DR조무수종적황반중심요시망막후도、신경상피층후도잉유현저증가。<br> 결론：응용mfERG가이재시망막무가견명현결구개변지전발현시망막공능상적이상변화；Spectralis OCT 가이측량시망막각층후도，반영시망막정세결구변화，험증시망막공능상적이상개변，이자연합응용위겁조기발현당뇨병시망막병변시공능개변제공유효적증거，병위급시치료제공자료。
AIM: To analyze the relationship between retinal function and retinal thickness in fovea in the patients of nonproliferative diabetic retinopathy ( NPDR ) without macular edema. <br> METHODS:Multifocal electronic retinography ( mfERG) and Spectralis optical coherence tomography ( Spectralis OCT) examination were performed in 35 eyes of 20 NPDR patients without macular edema. Twenty eyes of 19 normal subjects underwent the mfERG and 15 eyes of 10 normal subjects underwent Spectralis OCT. <br> RESULTS: Compared with normal group, the response densities P1 wave in Ring1 decreased and the change of latency of P1 wave and N1 wave had no statistical significance ( P<0.05 ). The retinal and neurosensory retinal thickness in fovea were thicker than normal. <br> CONCLUSION:The application of mfERG can detect the abnormal changes in retina without obvious structural changes, Spectralis OCT can measure the thickness of retinal layers, reflect the changes of retinal fine structure, and identify the abnormal changes of retinal structure. The associated examination of these two instruments offered available evidences in detecting visual function change in early DR, and offer information for therapy in time.
