CAJ | 학술논문

硫化氢（ hydrogen sulfide ，H2 S）是继NO和CO之后发现的第三种内源性气体信号分子。众多研究表明H2 S供体化合物参与舒张血管、抑制平滑肌增殖、保护缺氧神经元、抗炎、抗氧化应激、抗缺血/再灌注损伤等各种生理病理过程。目前的研究主要集中在心血管循环系统及神经系统，&nbsp；H2 S在糖尿病（ diabetes mellitus ，DM）及糖尿病性视网膜病变（diabetic retinopathy ，DR）等方面的研究少有报道。但H2 S的生理病理学作用与DR发生发展的病理过程在理论上有多方面的相关性。目前有少量研究通过模型动物实验验证H2 S在DR发生发展过程中的保护性作用，本文就从分子层面对H2 S在DR发病机制中的保护作用及研究进展作一综述。
류화경（ hydrogen sulfide ，H2 S）시계NO화CO지후발현적제삼충내원성기체신호분자。음다연구표명H2 S공체화합물삼여서장혈관、억제평활기증식、보호결양신경원、항염、항양화응격、항결혈/재관주손상등각충생리병리과정。목전적연구주요집중재심혈관순배계통급신경계통，&nbsp；H2 S재당뇨병（ diabetes mellitus ，DM）급당뇨병성시망막병변（diabetic retinopathy ，DR）등방면적연구소유보도。단H2 S적생리병이학작용여DR발생발전적병리과정재이론상유다방면적상관성。목전유소량연구통과모형동물실험험증H2 S재DR발생발전과정중적보호성작용，본문취종분자층면대H2 S재DR발병궤제중적보호작용급연구진전작일종술。
H2 S is the third kind of endogenous gaseous signal molecule after NO and CO. Numerous studies have shown that H2 S was involved in vasodilation, inhibiting smooth muscle proliferation, protecting hypoxic neurons, anti-inflammatory, anti-oxidation stress, anti-ischemia/reperfusion injury and other physiological/pathological processes.The present studies mainly concentrate on the circulatory system and nervous system rather than diabetes mellitus and diabetic retinopathy (DR).But the physiological and pathological effects of H2 S and the pathological process of DR have various correlations in many ways in theory.In this paper, the progress and protection of H2 S on the pathogenesis of DR are reviewed at the angle of molecular and cellular.