CAJ | 학술논문

目的：研究复方甘草酸苷对激素依赖性皮炎患者外周血激素水平和炎性因子的影响。方法收集确诊的激素依赖性皮炎患者68例作为观察组，同期健康体检者62例作为健康对照组，观察组均予为期4周的维生素E软膏外涂，复方甘草酸苷片口服治疗。比较观察组治疗前后及对照组血皮质醇、IL-10、IFN-γ、T N F-α水平。结果观察组治疗优良率为80．9％（55/68）。观察组治疗前后外周皮质醇水平差异无统计学意义（ P＞0．05），与对照组比较差异均无统计学意义（ P＞0．05）。观察组治疗前后外周血IL-10、IFN-γ、T N F-α差异均具有统计学意义（ P＜0．05）；治疗后血IFN-γ、TNF-α水平与健康对照组相比较差异无统计学意义（P＞0．05），治疗后血IL-10水平与健康对照组相比较差异具有统计学意义（P＜0．05）。结论复方甘草酸苷对激素依赖性皮炎患者外周血激素水平无明显影响，但是能够抑制炎性因子的过度分泌，减轻局部炎症，值得临床进一步推广研究。
목적：연구복방감초산감대격소의뢰성피염환자외주혈격소수평화염성인자적영향。방법수집학진적격소의뢰성피염환자68례작위관찰조，동기건강체검자62례작위건강대조조，관찰조균여위기4주적유생소E연고외도，복방감초산감편구복치료。비교관찰조치료전후급대조조혈피질순、IL-10、IFN-γ、T N F-α수평。결과관찰조치료우량솔위80．9％（55/68）。관찰조치료전후외주피질순수평차이무통계학의의（ P＞0．05），여대조조비교차이균무통계학의의（ P＞0．05）。관찰조치료전후외주혈IL-10、IFN-γ、T N F-α차이균구유통계학의의（ P＜0．05）；치료후혈IFN-γ、TNF-α수평여건강대조조상비교차이무통계학의의（P＞0．05），치료후혈IL-10수평여건강대조조상비교차이구유통계학의의（P＜0．05）。결론복방감초산감대격소의뢰성피염환자외주혈격소수평무명현영향，단시능구억제염성인자적과도분비，감경국부염증，치득림상진일보추엄연구。
Objective To study the effect of compound glycyrrhizin on peripheral blood hormone levels and the inflammatory factors in the patients with hormone-dependent dermatitis .Methods 68 patients with hormone-depend-ent dermatitis were collected as the observation group ,contemporaneous 62 subjects with the healthy physical exami-nation were chosen as the normal control group .The observation group was given Vitamin E Ointment for 4-week topical application and oral Compound Glycyrrhizin Tablets .Serum cortisol ,IL-10 ,IFN-gamma and TNF-alpha levels were compared between before and after treatment in the observation group and between the two groups .Results The excellent rate of the observation group was 80 .9% (55/68) .The peripheral cortisol levels in the observation group had no statistically significant difference between before and after treatment (P>0 .05) and no statistically sig-nificant difference compared with the control group (P>0 .05) .Peripheral blood IL-10 ,IFN-gamma and TNF-alpha before and after treatment in the observation group had statistical difference (P<0 .05);compared with the healthy control group ,blood IFN-gamma and TNF-alpha level after treatment in the observation group had no statistically significant(P>0 .05) ,compared with the healthy control group ,the blood IL-10 level after treatment in the observa-tion group had statistically significant (P<0 .05) .Conclusion Compound glycyrrhizin has no significant influence on the peripheral hormone level in the patients with hormone-dependent dermatitis ,but can inhibit the excessive secre-tion of inflammatory factors and reduce the local inflammation ,which is worth further clinical research .