CAJ | 학술논문

目的：分析短期应用胰岛素进行强化治疗对于2型糖尿病（T2DM ）患者的胰岛β细胞功能以及血糖控制水平的影响。方法收集初诊T2DM患者46例，以胰岛素泵进行治疗2周以后，测定患者治疗前后的血糖以及胰岛素变化情况，并计算患者的胰岛β细胞功能指数（HOM A-β）以及胰岛素抵抗指数（HOM A-IR），并观察血糖控制情况。结果患者的胰岛素水平、HOM A-β均较治疗前明显提高，HOM A-β以及血糖水平均明显降低（ P＜0．05）；16例患者仅依靠运动以及饮食控制便取得了理想的血糖控制效果。结论对初诊 T2DM 患者实施短期胰岛素泵治疗能够快速控制血糖水平，有效改善其胰岛β细胞功能，并可减轻患者的胰岛素抵抗，值得推广应用。
목적：분석단기응용이도소진행강화치료대우2형당뇨병（T2DM ）환자적이도β세포공능이급혈당공제수평적영향。방법수집초진T2DM환자46례，이이도소빙진행치료2주이후，측정환자치료전후적혈당이급이도소변화정황，병계산환자적이도β세포공능지수（HOM A-β）이급이도소저항지수（HOM A-IR），병관찰혈당공제정황。결과환자적이도소수평、HOM A-β균교치료전명현제고，HOM A-β이급혈당수평균명현강저（ P＜0．05）；16례환자부의고운동이급음식공제편취득료이상적혈당공제효과。결론대초진 T2DM 환자실시단기이도소빙치료능구쾌속공제혈당수평，유효개선기이도β세포공능，병가감경환자적이도소저항，치득추엄응용。
Objective To analyze the influence of the short-term intensive insulin therapy on the pancreatic is-letβ-cell function and the glycemic control level in the patients with type 2 diabetes mellitus(T2DM ) .Methods 46 patients with newly diagnosed T2DM were collected .After 2-week insulin pump therapy ,blood glucose and the insu-lin changes were measured before and after treatment and the pancreatic islet β-cell function index (HOMA-β) was calculated .The glycemic control condition was observed .Results The insulin levels and HOMA-βwere significantly increased than before treatment ,HOMA-β,and blood glucose level were significantly reduced (P<0 .05);16 cases a-chieved the ideal glycemic control effect by relying on the exercise and the diet control alone .Conclusion Implemen-ting the short-term insulin pump therapy in the newly diagnosed T2DM patients can quickly control the blood sugar levels and effectively improve the pancreatic islet β-cell function and reduce the patient′s insulin resistance ,which is worthy of being widely promoted and applied .