CAJ | 학술논문

目的：探讨周围型肺癌患者的CT 表现、血清肿瘤标记物及Ki-67、p53的蛋白表达的相关性。方法回顾性分析2008年1月至2011年12月周围型肺癌76例患者的C T和血清肿瘤标记物资料，评价不同病理类型的周围型肺癌的CT表现，Ki-67、p53蛋白表达与血清癌胚抗原（CEA）、神经元特异性烯醇化酶（NSE）、细胞角蛋白19片段的关系。结果不同病理类型的周围型肺癌，其C T表现毛刺征、分叶征、胸膜凹陷征的阳性率差异有统计学意义（P＜0．05）；鳞癌的Ki-67水平高于腺癌。结论血清肿瘤标志物联合影像检测能够提高肿瘤的检出率。Ki-67、p53的表达程度能反映肿瘤的恶性程度。
목적：탐토주위형폐암환자적CT 표현、혈청종류표기물급Ki-67、p53적단백표체적상관성。방법회고성분석2008년1월지2011년12월주위형폐암76례환자적C T화혈청종류표기물자료，평개불동병리류형적주위형폐암적CT표현，Ki-67、p53단백표체여혈청암배항원（CEA）、신경원특이성희순화매（NSE）、세포각단백19편단적관계。결과불동병리류형적주위형폐암，기C T표현모자정、분협정、흉막요함정적양성솔차이유통계학의의（P＜0．05）；린암적Ki-67수평고우선암。결론혈청종류표지물연합영상검측능구제고종류적검출솔。Ki-67、p53적표체정도능반영종류적악성정도。
Objective To explore the correlation among the CT findings ,serum tumor markers and the protein expression of Ki-67 and p53 in the patients with peripheral lung cancer .Methods The data of CT findings and serum tumor markers in 76 cases of peripheral lung cancer from January 2008 to December 2011 were retrospectively ana-lyzed for evaluating the correlation among CT findings ,protein expression of Ki-67 and p53 and serum CEA ,NSE , CYFRA21-1 in different pathological types of peripheral lung cancer .Results In different pathological types of pe-ripheral lung cancer ,the positive rates of the CT manifestations of spiculation ,lobulation and pleural indentation had statistical difference ;the Ki-67 content of squamous cell carcinoma was higher than that of adenocarcinoma .Conclu-sion Serum tumor markers combined with the imageological examination can increase the tumor detection rate .The expression degree of Ki-67 and p53 is the important indicator reflecting the tumor malignancy degree .