CAJ | 학술논문

目的比较芍倍注射液与消痔灵注射液注射治疗直肠脱垂的疗效及安全性.方法前瞻性入组2008年3月至2012年1月间佛山市南海区第四人民医院收治的80例Ⅰ～Ⅱ度直肠脱垂患者,按随机数字表法随机分为治疗组(40例,芍倍注射液注射法)和对照组(40例,消痔灵注射液四步注射法).以术后6月排粪造影显示的直肠脱垂长度作为近期疗效指标,结合术后2年的临床症状及排粪造影结果来评估远期疗效,并观察术后并发症及远期后遗症以评价治疗安全性.结果术后6月排粪造影显示,治疗组中位直肠脱垂长度由术前的5 cm减少为0.5cm,对照组则由术前的5 cm减少为1 cm,差异均有统计学意义(均P＜0.01).术后2年,治疗组和对照组分别有37例(92.5％)和35例(87.5％)患者获得痊愈,两组患者远期疗效的差异无统计学意义(P＞0.05).治疗组肛门局部不良反应发生率为10％(4/40),明显低于对照组的45％(18/40) (P＜0.01).结论芍倍注射液注射法治疗Ⅰ～Ⅱ度直肠脱垂能取得与消痔灵硬化疗法相当的近、远期疗效,且其安全性显著提高.
목적 비교작배주사액여소치령주사액주사치료직장탈수적료효급안전성.방법 전첨성입조2008년3월지2012년1월간불산시남해구제사인민의원수치적80례Ⅰ～Ⅱ도직장탈수환자,안수궤수자표법수궤분위치료조(40례,작배주사액주사법)화대조조(40례,소치령주사액사보주사법).이술후6월배분조영현시적직장탈수장도작위근기료효지표,결합술후2년적림상증상급배분조영결과래평고원기료효,병관찰술후병발증급원기후유증이평개치료안전성.결과술후6월배분조영현시,치료조중위직장탈수장도유술전적5 cm감소위0.5cm,대조조칙유술전적5 cm감소위1 cm,차이균유통계학의의(균P＜0.01).술후2년,치료조화대조조분별유37례(92.5％)화35례(87.5％)환자획득전유,량조환자원기료효적차이무통계학의의(P＞0.05).치료조항문국부불량반응발생솔위10％(4/40),명현저우대조조적45％(18/40) (P＜0.01).결론 작배주사액주사법치료Ⅰ～Ⅱ도직장탈수능취득여소치령경화요법상당적근、원기료효,차기안전성현저제고.
Objective To explore the safety and efficacy of Shaobei injection in the management of Ⅰ-Ⅱ degree rectal prolapse.Methods A total of 80 patients eligible for the inclusion criteria were divided into 2 groups:40 patients in the treatment group (treated with Shaobei injection) and 40 cases in the control group (treated with Xiaozhiling) respectively.The short-term efficacy was identified by the length of rectal prolapse and the depth of rectocele demonstrated by the defecography while the long-term efficacy was evaluated by the length of rectal prolapse.In addition,the safety was assessed by the occurrence of postoperative complications.Results The variation of the lengths of rectal prolapse and the depth of rectocele demonstrated by the defecography at the sixth month follow up in the two groups did not reach significant difference(P＞0.05).After 2 year follow up,37 patients (92.5％) in the treatment group and 35 cases (87.5％) in the control group was cured.Therefore,there was no significant difference in the long term efficacy between the two groups (P＞0.05).The adverse events in the therapy group(10％) was less than that in the control group(45％)(P＜0.01).Conclusions Shaobei injection in the management of Ⅰ-Ⅱ degree rectal prolapse has a similar efficacy of short-term and long-term higher safety compared to Xiaozhiling injection.